The results obtained in the present study suggest that in vitro Type III Cgs isolated from the blood of SCZ patients may induce the expression of proinflammatory and chemotactic
cytokines IL-1[beta], IL-6, TNF-[alpha] and IL-8, and MCP-1, respectively, by PBMCs.
Othmer, "Development and applications of a model for cellular response to multiple chemotactic
cues," Journal of Mathematical Biology, vol.
They have a chemotactic
response to neutrophils .
Seppa et al., "Platelet-derived growth factor is chemotactic
for fibroblasts," Journal of Cell Biology, vol.
KL-6, a human MUC1 mucin, is chemotactic
for human fibroblasts.
TNF-[alpha], 1[beta]-and IL-10 levels for overall inflammatory induction or MCP-1 or IL-8 for chemotactic
processes (Bry and Hallman, 1991; Dinarello, 1997)).
Probable reason of this incremental effect is that lornoxicam inhibits human polymorphoneuclear cell migration induced by f -myeloperoxidase, IL-8 and substance P (17) which are some of the important chemotactic
mediators of inflammation.
Monocyte -derived neuthrophil chemotactic
factor interleukin-8 is a potential mediator of crystal-induced inflammation.
Some of the evidence that implicates pyrin as a regulator of inflammation includes its interaction with leukocyte cytoskeleton, the death domain contained within the protein and its ability to deregulate chemotactic
factors recruit more of these cells to the site, and the destructive process perpetuates.
Nasreen demonstrated that when mesothelial cells are incubated with talc, citokynes such as interleukin-8 and monocyte chemotactic
protein-1 are released (7), and a randomised trial suggested that post-pleurodesis hypoxaemia is due to generalised lung inflammation as well as increased systemic inflammation (8).