chemosensitize

chemosensitize

(kē-mō-sen'si-tīz),
To alter susceptibility of a target cell or organism, such that a therapeutic agent, having become ineffective, becomes effective again; observed with antineoplastic and antiparasitic drugs.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
miR-200 family members have been previously reported to target p38a, modulate OS response and chemosensitize cancer cells [123].
Targeting RAS-MAPKERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma.
Resveratrol's ability to chemosensitize cancers to therapy has been attributed to the regulation of many signaling molecules including drug transporters, cell survival and cell proliferation regulators, and members of the nuclear factor kappa B and signal transducer and activator of transcription 3 signaling pathways (5).
So et al., "Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo," Molecular Cancer Therapeutics, vol.
studied the controlled release of etanidazole, a compound that is cytotoxic to tumor cells and can chemosensitize some alkylating agents by activating their tumor cell killing capabilities, encapsulated in sprayed dried poly(DL-lactide-co-glycolide) (PLGA) microspheres and compressed into implantable discs.
We proposed a so-called nematocyst release response controlled by soluble, prey-derived chemicals also known to both chemosensitize nematocyst discharge and initiate the feeding response.
Dai et al., "Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa," Molecular Cancer Therapeutics, vol.
Lev-Ari, "Escin chemosensitizes human pancreatic cancer cells and inhibits the nuclear factor-kappaB signaling pathway," Biochemistry Research International, vol.
Zhang et al., "MicroRNA-195 chemosensitizes colon cancer cells to the chemotherapeutic drug doxorubicin by targeting the first binding site of BCL2L2 mRNA," Journal of Cellular Physiology, vol.
Conclusion: In brief, our results suggested that resveratrol chemosensitizes doxorubicin in combination, through inhibiting breast cancer cells proliferation and invasion, and inducing apoptosis via suppression of chronic inflammation and autophagy.