Since head and neck cancers are
chemosensitive malignancies7, the introduction of induction chemotherapy followed by CCRT has several theoretical advantages, including reduced risk of distant failure/metastasis, induction of tumor shrinkage to allow more effective and less toxic local therapy, and prediction of tumor response8.
Chronic lymphocytic leukemia treated with targeted or biologic therapies and bulky,
chemosensitive solid tumors increases the patient's risk to intermediate.
Compared with allo-HSCT patients, auto-HSCT patients were more likely in first CR ( P = 0.001), and with
chemosensitive disease ( P < 0.001), and fewer lines of pretreatment ( P < 0.001).
The only thing most people knew was that it was very
chemosensitive and should be curable, but it's only curable if you follow the appropriate algorithms," he continued.
Plasmacytoid urothelial carcinoma, a
chemosensitive cancer with poor prognosis and peritoneal carcinomatosis.
High-dose chemotherapy followed by autologous stem cell rescue (HDT/ASCR) is the treatment of choice for patients with
chemosensitive disease at relapse.
These mediators stimulate
chemosensitive nociception, developing abdominal constrictions (Bukhari et al., 2013; Ferreira et al., 2013).
[2] Median survival is ~3-12 months, but can vary significantly according to cell type, performance status of the patient, staging and whether a
chemosensitive malignancy is present.
Of note, the study also included patients with advanced gastrointestinal cancer who were receiving first-line treatment for metastatic disease (albeit with
chemosensitive disease).
Chevreau et al., "High-dose chemotherapy consolidation for
chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial," Annals of Oncology, vol.
This clearly makes basal tumors more
chemosensitive compared to luminal A tumors, though it does not revert their poor survival probability and this category urgently needs additional treatment targets.
Based on the results of this analysis, CT could be considered as an appropriate treatment option in patients with newly diagnosed GCT who present MSCCS, as well as those with no more than two previous treatment regimens if the disease is
chemosensitive. In patients who have received 2 or more cycles of CT, RT/CT may be an option [5].