DelMar has demonstrated that VAL-083's anti-tumor activity is unaffected by common mechanisms of chemoresistance
, including MGMT, in cancer cell models and animal studies.
She has discovered a mechanism of chemoresistance
in metaplastic breast carcinoma, an aggressive subtype of triple-negative breast cancer.
In serous epithelial ovarian cancer, over-expression of Sirt1 contributes to chemoresistance
and poor prognosis (17).
Key Study Results: Increased serum and tumor GAS6 levels are associated with chemoresistance
and decreased progression free survival in patients with high-grade serous ovarian cancer undergoing neoadjuvant treatment.
Through data from their study, they have the potential to shed light on BMME mechanisms which may be involved in the development of chemoresistance
in AML cells.
Furthermore, two studies found that high serum levels of YKL-40 were associated with chemoresistance
Diagnostic assessment of osteosarcoma chemoresistance
based on virtual clinical trials.
For example, miR-101 could enhance paclitaxel (PTX)-induced apoptosis in NSCLC. MiR-216b was able to sensitize NSCLC cells to cisplatin-induced apoptosis. Moreover, miR-129-5p could also overcome resistance to cisplatin in NSCLC cells. Hence, it would be interesting to investigate whether miR-125-1-3p also possesses the ability to overcome chemoresistance
Its proprietary technology platform enables the development of highly specific monoclonal antibody therapeutics, including ADCs, targeting cancer cell surface glycans called TACAs, an emerging set of tumor-specific antigens implicated in immune suppression, chemoresistance
, and a CSC phenotype.
Combination of progesterone was found to overcome autophagy-related chemoresistance
and allowed effective cancer cell elimination (54).