DelMar has demonstrated that VAL-083's anti-tumor activity is unaffected by common mechanisms of
chemoresistance in vitro.
NEDD4-1 may regulate the proliferation, invasion, migration, and
chemoresistance of lung ADC cells through the PI3K/Akt pathway, suggesting that it may be regarded as a therapeutic target for the treatment of lung ADC.
15,64] Hypoxia-induced autophagy also imparted
chemoresistance in HCC cells.
The poor response to chemotherapy is hypothesized to be due to either
chemoresistance commonly seen in neuroendocrine tumors of other sites, or the lack of an appropriately determined regimen.
33 A lower Bax/Bcl-2 ratio is associated with
chemoresistance and adverse cytogenetics in AML.
Therefore, novel strategies to overcome
chemoresistance are urgently required.
The higher urolithin A concentration mixture was most effective at inhibiting the number and size of colon-cancer stem cells and inhibiting the activity of aldehyde dehydrogenase, a marker of
chemoresistance.
This nanoparticle formulation provides new and promising properties, including overcoming the mechanisms of
chemoresistance developed by tumour cells that affect the efficacy of chemotherapy agents.
Currently, authors advocate that the recurrence and
chemoresistance are the main problems for its treatment.
Dr Gottesman, whose research interests include mechanisms by which cancers become resistant to chemotherapy, reinforced in his keynote address that traditional monolayer cell culture models used to study tumor
chemoresistance have proven to be woefully inadequate.
53) Although it remains to be elucidated whether the altered metabolism directly affects carcinogenesis or
chemoresistance, it seems likely that metabolism plays an important role in reprogramming cancer cells to the pluripotent state.
Immediate and transient phosphorylation of the heat shock protein 27 initiates
chemoresistance in prostate cancer cells.
