DelMar has demonstrated that VAL-083's anti-tumor activity is unaffected by common mechanisms of chemoresistance
NEDD4-1 may regulate the proliferation, invasion, migration, and chemoresistance
of lung ADC cells through the PI3K/Akt pathway, suggesting that it may be regarded as a therapeutic target for the treatment of lung ADC.
15,64] Hypoxia-induced autophagy also imparted chemoresistance
in HCC cells.
The poor response to chemotherapy is hypothesized to be due to either chemoresistance
commonly seen in neuroendocrine tumors of other sites, or the lack of an appropriately determined regimen.
33 A lower Bax/Bcl-2 ratio is associated with chemoresistance
and adverse cytogenetics in AML.
Therefore, novel strategies to overcome chemoresistance
are urgently required.
The higher urolithin A concentration mixture was most effective at inhibiting the number and size of colon-cancer stem cells and inhibiting the activity of aldehyde dehydrogenase, a marker of chemoresistance
This nanoparticle formulation provides new and promising properties, including overcoming the mechanisms of chemoresistance
developed by tumour cells that affect the efficacy of chemotherapy agents.
Currently, authors advocate that the recurrence and chemoresistance
are the main problems for its treatment.
Dr Gottesman, whose research interests include mechanisms by which cancers become resistant to chemotherapy, reinforced in his keynote address that traditional monolayer cell culture models used to study tumor chemoresistance
have proven to be woefully inadequate.
53) Although it remains to be elucidated whether the altered metabolism directly affects carcinogenesis or chemoresistance
, it seems likely that metabolism plays an important role in reprogramming cancer cells to the pluripotent state.
Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance
in prostate cancer cells.