Thus, VC-III can serve as a suitable
chemoprotectant and increase the therapeutic window of CDDP in cancer patients.
Data collected from this will inform dose and schedule for further development of G1T28-1, either as a bone marrow
chemoprotectant or as an antineoplastic agent.
Therapeutic efficacy of aortic administration of N-acetylcysteine as a
chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
Amifostine as
chemoprotectant in metastatic breast cancer patients treated with doxorubicin.
Sodium thiosulfate has been shown to be a useful
chemoprotectant when used in conjunction with cisplatin.
Since broccoli has long been suspected to contain a
chemoprotectant, they tested it first.
NOV-002 is a small molecule compound based on a proprietary formulation of oxidized glutathione that acts together with chemotherapy as a chemopotentiator and a
chemoprotectant by regulating redox-sensitive cell signaling pathways.
NOV-002, the lead compound currently in Phase 3 development for lung cancer under an SPA and Fast Track, acts together with chemotherapy as a chemopotentiator and a
chemoprotectant.
BHA was used as a positive control to prove a
chemoprotectant in assorted animal models of specific carcinogenicity (Hocman, 1988; Iverson, 1995; Iverson, 1999).
The reported findings also support the concept that the dual actions of NOV-002 in cancer patients as both a chemopotentiator and a
chemoprotectant may reflect similar redox modulation in tumor and myeloid cells that results in opposite proliferative responses.
NOV-002, the lead compound currently in Phase 3 development for lung cancer under a SPA and Fast Track, acts together with chemotherapy as a
chemoprotectant and a chemopotentiator.
The research expands on earlier work in which scientists provided a close-up look at how other plant chemicals also act as
chemoprotectants by interfering with the flow of other biochemical signals.
