chemoprotectant

chemoprotectant

 
1. providing protection against the toxic effects of chemotherapy agents.
2. an agent that so acts.
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(2010) reported that quercetin (10, 30 and 100 mg/kg) for 5 consecutive days) ameliorates the diethylnitrosamine induced hepatotoxicity in rats and can be a candidate for a good chemoprotectant.
BGP-15 [O-(3-piperidino-2-hydroxy-1-propyl)-nicotinic acid], an HSP/chaperone inducer that was originally developed as a chemoprotectant, has been identified as a new type of insulin sensitizer with a novel pharmacological mechanism [75, 76].
Thus, VC-III can serve as a suitable chemoprotectant and increase the therapeutic window of CDDP in cancer patients.
Data collected from this will inform dose and schedule for further development of G1T28-1, either as a bone marrow chemoprotectant or as an antineoplastic agent.
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
Best known in medicine today for its vital contributions to heart and brain health, (1) exciting new discoveries point to broad and novel roles for CoQ10 as a "chemoprotectant" with tremendous promise as an adjuvant therapy in cancer treatment.
Sodium thiosulfate has been shown to be a useful chemoprotectant when used in conjunction with cisplatin.
Since broccoli has long been suspected to contain a chemoprotectant, they tested it first.
The anti-bacterial (Reinders et al., 2001), anti-viral (Thiel et al., 1984; Vlietinck et al., 1998), anti-protozoal (Shapiro et al., 1982), anti-fertility (Zheng et al., 1987), anti-steroidogenesis (Mele et al., 1997) and chemoprotectant (Adzet et al., 1987) activities are known to be exhibited by caffeic acid alone, whereas the anti-prostatis (Shoskes, 2002) anti-platelets (Pignatelli et al., 2000), anti-diarrhoeal (Galvez et al., 1993) and vasodilatory (Durate et al., 1993) activities are reported to be shown by quercetin.
BHA was used as a positive control to prove a chemoprotectant in assorted animal models of specific carcinogenicity (Hocman, 1988; Iverson, 1995; Iverson, 1999).