chemoprotectant

1. providing protection against the toxic effects of chemotherapy agents.

2. an agent that so acts.

Mentioned in ?

amifostine

References in periodicals archive ?

(2010) reported that quercetin (10, 30 and 100 mg/kg) for 5 consecutive days) ameliorates the diethylnitrosamine induced hepatotoxicity in rats and can be a candidate for a good chemoprotectant.

Protective Effect of Quercetin on Histomorphometric Changes in Kidney of Retinoid Acid-Treated Rat Fetuses/Efecto Protector de la Quercetina sobre los Cambios Histomorfometricos en el Rinon de Fetos de Rata Tratados con Acido Retinoico

BGP-15 [O-(3-piperidino-2-hydroxy-1-propyl)-nicotinic acid], an HSP/chaperone inducer that was originally developed as a chemoprotectant, has been identified as a new type of insulin sensitizer with a novel pharmacological mechanism [75, 76].

Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Thus, VC-III can serve as a suitable chemoprotectant and increase the therapeutic window of CDDP in cancer patients.

Role of Vanadium in Cellular and Molecular Immunology: Association with Immune-Related Inflammation and Pharmacotoxicology Mechanisms

Data collected from this will inform dose and schedule for further development of G1T28-1, either as a bone marrow chemoprotectant or as an antineoplastic agent.

G1 Therapeutics starts Phase I clinical trial of G1T28-1

Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.

The benefits of antioxidant combinations; a review of glutathione, NAC and glycine

Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin.

The protection of the myocardium by amifostine against mitoxantrone-induced acute cardiotoxicity in rats / Sicanlarda mitoksantronun yol actigi akut kardiyotoksisteye karsi amifostin ile miyokardin korunmasi

Best known in medicine today for its vital contributions to heart and brain health, (1) exciting new discoveries point to broad and novel roles for CoQ10 as a "chemoprotectant" with tremendous promise as an adjuvant therapy in cancer treatment.

Coenzyme Q10 and cancer: enhancing treatment outcomes and improving chemotherapy tolerability

chemoprotectant; 2004; Mendez-Albores enterosorption et al.

Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries

Sodium thiosulfate has been shown to be a useful chemoprotectant when used in conjunction with cisplatin.

Blood-brain barrier disruption for the treatment of malignant brain tumors: the national program

Since broccoli has long been suspected to contain a chemoprotectant, they tested it first.

Inside broccoli: a weapon against cancer

The anti-bacterial (Reinders et al., 2001), anti-viral (Thiel et al., 1984; Vlietinck et al., 1998), anti-protozoal (Shapiro et al., 1982), anti-fertility (Zheng et al., 1987), anti-steroidogenesis (Mele et al., 1997) and chemoprotectant (Adzet et al., 1987) activities are known to be exhibited by caffeic acid alone, whereas the anti-prostatis (Shoskes, 2002) anti-platelets (Pignatelli et al., 2000), anti-diarrhoeal (Galvez et al., 1993) and vasodilatory (Durate et al., 1993) activities are reported to be shown by quercetin.

Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents

BHA was used as a positive control to prove a chemoprotectant in assorted animal models of specific carcinogenicity (Hocman, 1988; Iverson, 1995; Iverson, 1999).

Modulatory effect of Urtica dioica L. (Urticaceae) leaf extract on biotransformation enzyme systems, antioxidant enzymes, lactate dehydrogenase and lipid peroxidation in mice

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