(2010) reported that quercetin (10, 30 and 100 mg/kg) for 5 consecutive days) ameliorates the diethylnitrosamine induced hepatotoxicity in rats and can be a candidate for a good chemoprotectant
BGP-15 [O-(3-piperidino-2-hydroxy-1-propyl)-nicotinic acid], an HSP/chaperone inducer that was originally developed as a chemoprotectant
, has been identified as a new type of insulin sensitizer with a novel pharmacological mechanism [75, 76].
Thus, VC-III can serve as a suitable chemoprotectant
and increase the therapeutic window of CDDP in cancer patients.
Data collected from this will inform dose and schedule for further development of G1T28-1, either as a bone marrow chemoprotectant
or as an antineoplastic agent.
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant
against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
Amifostine as chemoprotectant
in metastatic breast cancer patients treated with doxorubicin.
Best known in medicine today for its vital contributions to heart and brain health, (1) exciting new discoveries point to broad and novel roles for CoQ10 as a "chemoprotectant
" with tremendous promise as an adjuvant therapy in cancer treatment.
; 2004; Mendez-Albores enterosorption et al.
Sodium thiosulfate has been shown to be a useful chemoprotectant
when used in conjunction with cisplatin.
Since broccoli has long been suspected to contain a chemoprotectant
, they tested it first.
The anti-bacterial (Reinders et al., 2001), anti-viral (Thiel et al., 1984; Vlietinck et al., 1998), anti-protozoal (Shapiro et al., 1982), anti-fertility (Zheng et al., 1987), anti-steroidogenesis (Mele et al., 1997) and chemoprotectant
(Adzet et al., 1987) activities are known to be exhibited by caffeic acid alone, whereas the anti-prostatis (Shoskes, 2002) anti-platelets (Pignatelli et al., 2000), anti-diarrhoeal (Galvez et al., 1993) and vasodilatory (Durate et al., 1993) activities are reported to be shown by quercetin.
BHA was used as a positive control to prove a chemoprotectant
in assorted animal models of specific carcinogenicity (Hocman, 1988; Iverson, 1995; Iverson, 1999).