chemoprevention

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chem·o·pre·ven·tion

(kē'mō-prē-ven'shŭn),
The use of drugs or other agents to inhibit the development or progression of malignant changes in cells.

chemoprevention

(kē′mō-prĭ-vĕn′shən, kĕm′ō-)
n.
The use of chemical agents, drugs, or food supplements to prevent the development of cancer.

che′mo·pre·ven′tive adj. & n.

chemoprevention

the use of natural, synthetic or biological substances to suppress or prevent a disease such as cancer. Also called chemoprophylaxis.
Nutrition The use of drugs, chemicals, vitamins or other substances in the diet to prevent or decrease the incidence of a disease—e.g., cancer; chemopreventive agents—supported by some ‘soft’ epidemiologic data—are vitamin-rich fruits, bran, other dietary fibers, and cruciferous vegetables
Oncology Intervention with chemical agents before malignancy—invasion—across an epithelial basement membrane develops, to halt or slow carcinogenesis; chemoprevention aims to directly modulate specific steps in carcinogenesis, prevent DNA damage by free radicals, suppress epithelial proliferation, and promote epithelial differentiation

chemoprevention

Nutrition The use of drugs, chemicals, vitamins or other substance in the diet or to prevent or ↓ the incidence of a disease–eg, CA; chemopreventive agents–supported by 'soft' epidemiologic data are vitamins A, C, E, bran, other dietary fibers, and cruciferous vegetables. See Antioxidant, Antioxidant therapy. Cf Chemoprophylaxis, Unproven methods for cancer management.
References in periodicals archive ?
Chemopreventive agents are used to suppress, reduce or prevent the progression of carcinogenesis.
7,21,22) Most importantly, resveratrol is considered to act as a chemopreventive agent against skin cancer and antiproliferative influence on oral squamous, breast, colon, and prostate cancer cells.
Promising lab and animal studies have paved the way for a growing series of human studies investigating curcumin's chemopreventive properties.
in 2013 studied chemopreventive properties of fungus extracted polysaccharide from Rhizopus nigricans and reported that the isolated polysaccharide suppressed human gastric cancer BGC-823 cell growth, displayed [G.
chemopreventive, he said, adding that for every patient who refuses, there are probably 4 who agree to try the therapy, but "15 after that who never hear about it," because of gaps in knowledge in the primary care setting.
Researchers working in biology, biochemistry, pharmacology, and other sciences in the US, Europe, Asia, Argentina, and Israel discuss cystic fibrosis, nitric oxide signaling in the brain, the physiological functions of mammalian glutathione peroxidases and its role in inflammation-triggered carcinogenesis, molecular medicine and the development of cancer chemopreventive agents, thermal and athermal effects of water-filtered infrared A irradiation, and the relevance of acrolein effects in pulmonary cells to chronic obstructive pulmonary disease.
Kinghorn's work has focused on natural product compounds with potential anti-microbial, cancer chemotherapeutic, cancer chemopreventive, sweet-tasting, and bitterness-blocking effects.
It is thought that the ability of SFN to inhibit histone deacetylase (HDAC) enzymes may be one mechanism by which it acts as a chemopreventive agent.
Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like
The present study was undertaken to evaluate the combinatorial chemopreventive effects of bovine milk lactoferrin (bLF) and black tea polyphenols (Polyphenol-B) in a clinically relevant in vivo model of 7, 12-dimethylbenz[z]anthracene (DMBA)--induced male Syrian hamster buccal pouch (HBP) carcinogenesis.
The protein, called Nrf2, has been thought to be an important drug-therapy target for diseases such as cancer because it can induce chemopreventive activity.