That is particularly welcome news, as tamoxifen is at present the only chemopreventive
agent approved for premenopausal use, although the selective estrogen receptor modifier (SERM) raloxifene is undergoing regulatory review for this proposed indication.
These findings "can help to identify population subgroups defined by genetic background that may preferentially benefit from chemopreventive
use of these agents and offer novel insights into underlying mechanisms of carcinogenesis," said Dr.
Khuri's clinical expertise and research are focused on the development of molecular, prognostic, therapeutic and chemopreventive
approaches to improve the standard of care for patients with lung and aerodigestive cancers.
Epidemiological in vitro and in vivo studies have shown that both soy isoflavones and vitamin D are potential chemopreventive
Black raspberries, in particular, have been shown In numerous animal studies to have chemopreventive
effects on tumors in the mouth, esophagus, and colon.
We set out to create a product that had the same level of quality and stability you would find in a pharmaceutical medicine, but that was 100 percent fruit, simple to take and retained high levels of chemopreventive
bioactives," said Yael Vodovotz, PhD, a food scientist with The Ohio State University Department of Food Science and Technology, said.
Breast cancer chemopreventive
drugs such as tamoxifen should be covered as a preventive service with no out-of-pocket cost for high-risk women, according to the Health & Human Services department.
Green tea, the most popular beverage next to water, is a rich source of tea catechins and has potential to be developed as a chemopreventive
agent for prostate cancer.
Researchers working in biology, biochemistry, pharmacology, and other sciences in the US, Europe, Asia, Argentina, and Israel discuss cystic fibrosis, nitric oxide signaling in the brain, the physiological functions of mammalian glutathione peroxidases and its role in inflammation-triggered carcinogenesis, molecular medicine and the development of cancer chemopreventive
agents, thermal and athermal effects of water-filtered infrared A irradiation, and the relevance of acrolein effects in pulmonary cells to chronic obstructive pulmonary disease.
Kinghorn's work has focused on natural product compounds with potential anti-microbial, cancer chemotherapeutic, cancer chemopreventive
, sweet-tasting, and bitterness-blocking effects.
Dr Sale is currently researching the development of novel cancer chemopreventive
agents for the prevention of prostate, colorectal and lung cancer at the University of Leicester.
The present study was carried out on male Wistar rats to evaluate the chemopreventive
effects of eugenol (4-allyl-methoxyphenol), a natural phenolic constituent of clove oil, cinnamon, basil, and nutmeg, used primarily as a food flavouring agent, on NF-kB signaling, apoptosis, invasion, and angiogenesis during N-methyl-N-nitro-N-nitrosoguanidine (MNNG)--induced gastric carcinogenesis.