chemoprevention

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chem·o·pre·ven·tion

(kē'mō-prē-ven'shŭn),
The use of drugs or other agents to inhibit the development or progression of malignant changes in cells.
Farlex Partner Medical Dictionary © Farlex 2012

chemoprevention

(kē′mō-prĭ-vĕn′shən, kĕm′ō-)
n.
The use of chemical agents, drugs, or food supplements to prevent the development of cancer.

che′mo·pre·ven′tive adj. & n.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
Nutrition The use of drugs, chemicals, vitamins or other substances in the diet to prevent or decrease the incidence of a disease—e.g., cancer; chemopreventive agents—supported by some ‘soft’ epidemiologic data—are vitamin-rich fruits, bran, other dietary fibers, and cruciferous vegetables
Oncology Intervention with chemical agents before malignancy—invasion—across an epithelial basement membrane develops, to halt or slow carcinogenesis; chemoprevention aims to directly modulate specific steps in carcinogenesis, prevent DNA damage by free radicals, suppress epithelial proliferation, and promote epithelial differentiation
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

chemoprevention

Nutrition The use of drugs, chemicals, vitamins or other substance in the diet or to prevent or ↓ the incidence of a disease–eg, CA; chemopreventive agents–supported by 'soft' epidemiologic data are vitamins A, C, E, bran, other dietary fibers, and cruciferous vegetables. See Antioxidant, Antioxidant therapy. Cf Chemoprophylaxis, Unproven methods for cancer management.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
There is a requisite for novel chemopreventive compounds which are easily available, have good efficacy and safety profile.
evaluated the chemopreventive efficacy of free and encapsulated sesamol in a 7,12-dimethylbenz[a]-anthracene-induced skin cancer animal model.
Chemopreventive agents are used to suppress, reduce or prevent the progression of carcinogenesis.
Descriptive analyses were used to examine the two groups with regard to the following variables: age, family history, BRCA status, history of biopsy proven atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS), breast cancer histology, stage, estrogen receptor (ER)/progesterone receptor (PR)/HER2/neu status, type of chemopreventive agent used (tamoxifen, raloxifene, or AIs), duration of use, time between primary cancer and subsequent breast malignancy, and location of the breast cancer (contralateral versus ipsilateral).
Promising lab and animal studies have paved the way for a growing series of human studies investigating curcumin's chemopreventive properties.
They noted that, in some meta-analyses, referral center studies yielded chemopreventive effects that did not hold up in population-based cohorts.
Some chemopreventive polyphenol agents such as curcumin, ferulic acid and resveratrol are believed to inhibit proliferation of transformed cells by apoptosis induction, DNA fragmentation and regulation of signal transduction pathways.
Also, medicinal plants can serve as chemopreventive agents, which induce therapeutic outcomes that modulate the aggregation process of beta-amyloid, and provide measureable cognitive benefits in the aging process.
Furthermore, it is widely accessible as an inexpensive over-the-counter vitamin supplement and presents a new chemopreventive opportunity against NMSCs that is readily translatable into clinical practice.
This online pre-publication is titled 'Search for novel circulating cancer chemopreventive biomarkers of dietary rice bran intervention in ApcMin mice model of colorectal carcinogenesis, using proteomic and metabolic profiling strategies' and will appear in its final edited version in a future edition of the scientific journal.
Dot-blot assay and apoptosis results indicate that DNA damage due to UVB exposure is significantly reduced in the presence of silver nanoparticles in the size range 10-40 nm, thereby proving the chemopreventive effect of silver nanoparticles.