chemokines


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che·mo·kines (CC),

(kē'mō-kinz),
Several groups composed of usually 8-10 kD polypeptide cytokines that are chemokinetic and chemotactic, stimulating leukocyte movement and attraction.
Synonym(s): intercrines
[chemo- + G. kineō, to set in motion]

che·mo·kines

(kē'mō-kīnz)
Several groups composed of usually 8-10 kD polypepytide cytokines that are chemokinetic and chemotactic stimulating leukocyte movement and attraction.
Synonym(s): intercrines.
[chemo- + G. kineō, to set in motion]

chemokines

Chemotactic CYTOKINES, a family of about 50 structurally-related heparin-binding proteins that can induce activation and migration of specific types of white cell, attracting them to sites of inflammation by chemotaxis. They have a fundamental role in inflammation and are concerned in the immune system protective responses to infecting organisms. Chemokines are also concerned in ANGIOGENESIS. Chemokines are implicated in allergic rhinitis, rheumatoid arthritis, asthma, atherosclerosis, inflammatory bowel disease, COPD, insulin resistance, obesity-induced diabetes, multiple sclerosis and psoriasis. Chemokine-receptor antagonists are under active investigation.
References in periodicals archive ?
Chemokines that play a crucial role to recruit leukocyte subsets migration through the endothelium and into liver to against the virus during the progression of HCV infection can be secreted directly by the liver.12ACKR1 represents an atypical chemokine receptor that can bind promiscuously to various chemokines belonging to the CC and CXC families.13 Recent study found that ACKR1 polymorphism is associated with serum concentration of CCL2 belonging to the CC family.14 Moreover, the functional relevance of CCL2 has been demonstrated in experimental liver fibrosis models and patients with HCV infection.15
This integrin activation is induced by Gprotein coupled receptor (GPCR) signaling in the lymphocytes at HEVs, which is initiated by the lymphocytes' interaction with chemokines displayed on ECs via specific receptors.
Combadiere, "Role of chemokines polymorphisms in diseases," Immunology Letters, vol.
Chemokines, in particular inflammatory cytokines, can exert toxic effects via a direct mechanism, through binding to dopaminergic neurons, or by an indirect mechanism, through glial cell activation and the expression of inflammatory factors [3].
Human cells appear to use the same chemokine signals, leading to hopes it may point to new treatments for women.
Phosphodiesterase 4 inhibitors such as roflumilast have been shown to inhibit the release of several inflammatory cytokines and chemokines in LPS-stimulated macrophages.
The onset and progression of SIRS occurs because of dysregulation of the normal inflammatory response, usually with an increase in both proinflammatory and anti-inflammatory cytokines and chemokines, initiating a chain of events that leads to organ failure.