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che·mo·kines (CC),

Several groups composed of usually 8-10 kD polypeptide cytokines that are chemokinetic and chemotactic, stimulating leukocyte movement and attraction.
Synonym(s): intercrines
[chemo- + G. kineō, to set in motion]


Several groups composed of usually 8-10 kD polypepytide cytokines that are chemokinetic and chemotactic stimulating leukocyte movement and attraction.
Synonym(s): intercrines.
[chemo- + G. kineō, to set in motion]


Chemotactic CYTOKINES, a family of about 50 structurally-related heparin-binding proteins that can induce activation and migration of specific types of white cell, attracting them to sites of inflammation by chemotaxis. They have a fundamental role in inflammation and are concerned in the immune system protective responses to infecting organisms. Chemokines are also concerned in ANGIOGENESIS. Chemokines are implicated in allergic rhinitis, rheumatoid arthritis, asthma, atherosclerosis, inflammatory bowel disease, COPD, insulin resistance, obesity-induced diabetes, multiple sclerosis and psoriasis. Chemokine-receptor antagonists are under active investigation.


a large family of chemotactic cytokines which stimulate leukocyte movement.
References in periodicals archive ?
When investigators created mice lacking the chemokine receptor CXCR4, which is one that HIV exploits, the rodents died as embryos, their hearts and blood vessels riddled with defects.
HIV-I gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.
A mutation in a different gene for a chemokine called SDF actually accelerates the progression of HIV toward AIDS.
12ACKR1 represents an atypical chemokine receptor that can bind promiscuously to various chemokines belonging to the CC and CXC families.
To address this, we have now measured the concentrations of proinflammatory cytokines TNF-a, IL-1[sz], IL-6, and IL-17 and 11 CXC and CC chemokines in bronchial alveolar lavage fluid from a large cohort of 100 subjects (asthmatics = 70, including 37 mild and 33 moderate/severe asthmatics, and controls = 30).
Distinct Transcript Isoforms of the Atypical Chemokine Receptor 1 (ACKR1) / Duffy Antigen Receptor for Chemokines (DARC) Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele.
It was subsequently found that the lymphocytes' interaction with HEV ECs is directed by a sitespecific adhesion cascade involving several specific molecules and chemokines that act in sequence (Fig.
As the aforementioned chemokine receptors, there are classic (Gi) and alternative (Gq) coupled GPCR pathways depending on the specific type of the chemokines and chemokine-stimulated cells [38].
Keratinocytes have been implicated in inflammatory skin responses based on their production of pro-inflammatory chemokines (Brandt and Sivaprasad 2011), the levels of which are significantly higher in the lesional skin of chronic skin diseases patients (Kang et al.
3) Chemokines are a small group of molecules, which are defined by the presence of four cysteines in highly conserved region.