Chemokine receptor CCR5 | definition of chemokine receptor CCR5 by Medical dictionary
CCR5 (redirected from chemokine receptor CCR5)
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CCR5 A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.
A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
References in periodicals archive
The chemokine receptor CCR5
plays a key role in the early memory CD8+ T cell response to respiratory virus infections.
HGS004 is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5
, which is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1).
Macrophage-tropic (M-tropic) strains infect primary macrophages and primary lymphocytes and use the chemokine receptor CCR5
as a co-receptor.
Virus isolates recovered from infected individuals in the early stages of disease utilize chemokine receptor CCR5
(R5) exclusively as a coreceptor for cellular infection and do not induce syncitium formation in transformed T-cell lines in vitro (non-syncitium inducing or NSI).
CCR5 mAb (CCR5mAb004) is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5