CCR5

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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Chemokine receptor CCR5 in interferon-treated multiple sclerosis.
Thus, in addition to the expression of the chemokine receptor CCR5, expression of ligands of this receptor is responsible for the attraction of lymphocytes to the tumor microenvironment.
Haney et al., "Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents," European Journal of Medicinal Chemistry, vol.
Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.
Macrophage-tropic (M-tropic) strains infect primary macrophages and primary lymphocytes and use the chemokine receptor CCR5 as a co-receptor.
Virus isolates recovered from infected individuals in the early stages of disease utilize chemokine receptor CCR5 (R5) exclusively as a coreceptor for cellular infection and do not induce syncitium formation in transformed T-cell lines in vitro (non-syncitium inducing or NSI).
Dobbs et al., "Maraviroc (UK-427, 857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity," Antimicrobial Agents and Chemotherapy, vol.
Zhang, "Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1[alpha] by interferon-[beta]," Journal of Neuroimmunology, vol.