chemokine receptor


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Related to chemokine receptor: Chemokines

chemokine receptor

Abbreviation: CCR
Any of several protein receptors for chemokines that spans the cell membrane and links to intracellular G proteins. The cell-to-cell signaling and regulating effects of chemokines, e.g., on inflammation or hematopoiesis, are mediated through chemokine receptors, which can be blocked with specific antagonist drugs. CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. The virus uses these receptors to gain entry into T cells, macrophages, and other CD4+ cells.
See also: receptor

Chemokine receptor

A receptor on the surface of some types of immune cells that helps to mediate entry of HIV into the cell.
Mentioned in: AIDS
References in periodicals archive ?
Furthermore, this report also reviews key players involved in C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics development with respective active and dormant or discontinued projects.
Rivera-Nieves, "The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice," Gastroenterology, vol.
Chemokines that play a crucial role to recruit leukocyte subsets migration through the endothelium and into liver to against the virus during the progression of HCV infection can be secreted directly by the liver.12ACKR1 represents an atypical chemokine receptor that can bind promiscuously to various chemokines belonging to the CC and CXC families.13 Recent study found that ACKR1 polymorphism is associated with serum concentration of CCL2 belonging to the CC family.14 Moreover, the functional relevance of CCL2 has been demonstrated in experimental liver fibrosis models and patients with HCV infection.15
Conclusion: Our result indicates that atypical chemokine receptor 1 polymorphism (rs12075) does not affect susceptibility to hepatitis C virus.
(2014) The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes.
Wyld et al., "Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission," The Journal of Infectious Diseases, vol.
Each leukocyte subpopulation expresses a characteristic set of chemokine receptors that belong to the family of G protein-coupled receptors [13].
Abbadie, "Chemokines, chemokine receptors and pain," Trends in Immunology, vol.
A different picture emerges from studies on BM-MSCs, a stem cell type closely related to OE-MSCs [11]: on these cells, the expression of chemokine receptors and particularly CCR2 varies according to culture conditions and assessment techniques [64-67].
The report provides comprehensive information on the C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
HIV-1 and HIV-2 strains have been reported to be capable of utilising several alternative chemokine receptors, including CCR2b, CXCR4, CXCR6 and GPR1, to mediate infection of cells.
Nibbs et al., "The chemokine receptor D6 limits the inflammatory response in vivo," Nature Immunology, vol.