PF4(redirected from chemokine (C-X-C motif) ligand 4)
PF4A gene on chromosome 4q12-q21 that encodes a protein released from the alpha-granules of activated platelets which binds with high affinity to heparin. PF4’s major physiologic role appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, inhibiting antithrombin-III activity and promoting coagulation; as a chemoattractant for neutrophils and fibroblasts, PF4 likely plays a role in inflammation and wound repair.
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