chemokine

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Related to chemokine: cytokine, interleukin, Chemokine receptor

chemokine

/che·mo·kine/ (ke´mo-kīn) any of a group of low molecular weight cytokines identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation.

chemokine

(kē′mō-kīn′, kĕm′ō-)

Any of various cytokines produced in acute and chronic inflammation that mobilize and activate white blood cells.

chemokine

[kē′mōkīn]

Etymology: Gk, chemeia, alchemy + kinēsis, movement

any of a group of low-molecular-weight cytokines, such as interleukin-8, identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation. The group is divided into four subgroups on the basis of genetic, structural, and functional criteria. They function as regulators of the immune system and may also play roles in the circulatory and central nervous systems. See also cytokine.

CCL1

A gene on chromosome 17q12 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL1 is secreted by activated T cells and is chemotactic for monocytes but not neutrophils; it binds to chemokine receptor CCR8.

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The Duffy blood group antigens, also called Duffy antigen receptor for chemokines (DARC), recently renamed atypical chemokine receptor 1 (ACKR1).

Atypical Chemokine Receptor 1 polymorphism cannot be used as an indicator of liver fibrosis progression in Hepatitis C virus positive patients

Genotyping of atypical chemokine receptor 1 was performed using a 5'-nuclease assay with TaqMan-minor groove binding probes.

Atypical Chemokine Receptor 1 Polymorphism can not Affect Susceptibility to Hepatitis C Virus

The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5)

C-C Chemokine Receptor Type 5 - Pipeline Review, H1 2016: New Report

In a cell-based study, Arai and Charo [32] showed that monocyte chemotactic protein- (MCP-) 1-related chemokine receptors (mainly CC family receptors) interact with multiple subtypes of G proteins in a cell type-specific manner and that the third intracellular loop of CC type receptors mediates Gq coupling.

Gq-Coupled Receptors in Autoimmunity

Human CC chemokine (MIP-1[alpha]) was used as positive control.

Receptor expression and responsiveness of human peripheral blood mononuclear cells to a human cytomegalovirus encoded CC chemokine

Inhibition of phosphodiesterase 4 suppresses lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Th2 cells are attracted to the skin by inflammatory chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES); thymus and activation regulated chemokine (TARC); and macrophage-derived chemokine (MDC).

Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-[kappa]B in HaCaT cells

Chemokine receptor CCR5 was cloned in 1996 and is encoded by CMKBR gene located on 3p21.

Frequency of CCR5[DELTA]32 allele in healthy Bosniak population

Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells.

Genetic polymorphisms of CCL22 and CCR4 in patients with lung cancer

You can mix and match them, but you always need one of each--one selectin, one integrin and one chemokine, and each one's receptor--for immune cells to go into the brain.

Dr. Richard Ransohoff awarded 2012 Dystel Research Prize

R&D Systems, the major Cytokine and Chemokine Reagent and Kits supplier, is also profiled in the report.

Report available: Global Laboratory Chemical Reagents Industry

Nasdaq:CCXI) has announced publication of positive data from the company's Phase 2 CARAT-2 study for CCX354, a potent and selective, orally-administered inhibitor of CCR1, a chemokine receptor that drives the recruitment of inflammatory cells into the joints of patients with rheumatoid arthritis (RA).