We observed that T cells were absent from the part of the tumour containing the cancer cells that were coated with chemokine
, and the principal source of the chemokine
was the CAFs," said Professor Fearon.
Title: Rapid Mobilization Of CD34+ Stem Cells With TG-0054, a Novel CXC Chemokine
Receptor 4 (CXCR4) Antagonist Session Name: 711.
Ransohoff considers himself lucky to have "tripped over" this discovery, which introduced him to the relatively new field of chemokine
CCX354 has been shown to be a potent and selective antagonist of CCR1, a chemokine
receptor that drives the recruitment of certain inflammatory cells including populations of monocytes, macrophages and T cells into the joints of patients with RA.
In studies looking at chemokine
receptor expression and function in osteosarcoma cell lines and tissues from osteosarcoma patients, the results showed that messenger RNA (mRNA) and protein expression of CXCR4 were correlated with neoplastic progression, in line with other solid tumors.
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine
are small proteins in the cytokine family that bind to chemokine
receptors promoting a large number of functions among which, more importantly, the development and homeostasis of the immune system, the cellular movement by chemotaxis, the stem cell survival, the angiogenesis.
Isolating the CXCR7 receptor from potential interference by other chemokine
receptors (such as the related receptor known as CXCR4), researchers demonstrated that CXCR7 cells formed significantly larger tumors in breast and lung cancer models.
Room 207 Detailed results from ChemoCentryx's Phase 2 randomized clinical trial will be provided in an oral presentation (#1031) titled "CCX282-B, an orally active inhibitor of chemokine
receptor CCR9, shows anti-inflammatory and clinical activity in the treatment of Crohn's Disease" by Satish Keshav, M.
Hassan Salari, President and CEO of Chemokine
Stelic's Stem Cell Dynamism Research Team has shown that hepatic cord regeneration in acute liver cell damage is regulated at the in vivo level by a protein called chemokine
The mutation that has been implicated in West Nile disease susceptibility shuts down the production of a protein called chemokine