chemokine


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Related to chemokine: cytokine, interleukin, Chemokine receptor

chemokine

/che·mo·kine/ (ke´mo-kīn) any of a group of low molecular weight cytokines identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation.

chemokine

(kē′mō-kīn′, kĕm′ō-)
n.
Any of various cytokines produced in acute and chronic inflammation that mobilize and activate white blood cells.

chemokine

[kē′mōkīn]
Etymology: Gk, chemeia, alchemy + kinēsis, movement
any of a group of low-molecular-weight cytokines, such as interleukin-8, identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation. The group is divided into four subgroups on the basis of genetic, structural, and functional criteria. They function as regulators of the immune system and may also play roles in the circulatory and central nervous systems. See also cytokine.

CCL1

A gene on chromosome 17q12 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL1 is secreted by activated T cells and is chemotactic for monocytes but not neutrophils; it binds to chemokine receptor CCR8.
References in periodicals archive ?
The Duffy blood group antigens, also called Duffy antigen receptor for chemokines (DARC), recently renamed atypical chemokine receptor 1 (ACKR1).
Genotyping of atypical chemokine receptor 1 was performed using a 5'-nuclease assay with TaqMan-minor groove binding probes.
The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5)
In a cell-based study, Arai and Charo [32] showed that monocyte chemotactic protein- (MCP-) 1-related chemokine receptors (mainly CC family receptors) interact with multiple subtypes of G proteins in a cell type-specific manner and that the third intracellular loop of CC type receptors mediates Gq coupling.
Inhibition of phosphodiesterase 4 suppresses lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages
Th2 cells are attracted to the skin by inflammatory chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES); thymus and activation regulated chemokine (TARC); and macrophage-derived chemokine (MDC).
Chemokine receptor CCR5 was cloned in 1996 and is encoded by CMKBR gene located on 3p21.
Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells.
You can mix and match them, but you always need one of each--one selectin, one integrin and one chemokine, and each one's receptor--for immune cells to go into the brain.
R&D Systems, the major Cytokine and Chemokine Reagent and Kits supplier, is also profiled in the report.
Nasdaq:CCXI) has announced publication of positive data from the company's Phase 2 CARAT-2 study for CCX354, a potent and selective, orally-administered inhibitor of CCR1, a chemokine receptor that drives the recruitment of inflammatory cells into the joints of patients with rheumatoid arthritis (RA).

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