chemoattractants


Also found in: Dictionary.
Related to chemoattractants: chemotaxis, chemotaxin, chemotactic

che·mo·at·tract·ants

(kē'mō-a-trak'tints),
Chemical substances that influence the recruitment and migration of cells.
[chem- + attract + -i]
References in periodicals archive ?
To clarify the immune responses mediated by ficolins in the placenta during preeclamptic pregnancy, we found that chemokines/cytokines involved in innate immunity, including monocyte chemoattractant proteins 1/2/3 (MCP1/2/3), monokine induced by gamma-interferon (MIG), macrophage inflammatory proteins 1[delta]/3[alpha] (MIP1[delta]/3[alpha]), tumor necrosis factor [alpha] (TNF[alpha]) and thymus expressed chemokine (TECK) were activated, whereas interferon/cytokines involved in adaptive immunity, including interferon [gamma] (IFN[gamma]), interleukin 13/4/5 (IL13/4/5), transforming growth factor [beta]1/[beta]3 (TGF[beta]1/[beta]3) and TNF[beta], were suppressed in preeclamptic placenta (n = 10 vs 10; Fig.
Using real-time reverse transcriptase-polymerase chain reaction (RT-PCR), we measured the mRNA levels of eight genes [interleukin (IL)-1[beta] IL-6, IL-10, iNOS (inducible nitric oxide synthase), MCP-1 (monocyte chemoattractant protein-I), MIP-2 (macrophage inflammatory protein-2), TGF-[beta]1 (transforming growth factor-[beta]1), and TNF-[alpha] (tumor necrosis factor-[alpha]] in BAL cells and four genes [IL-6, ICAM-1 (intercellular adhesion molecule-1), GM-CSF (granulocyte/macrophage-colony stimulating factor), and RANTES (regulated upon activation normal T cell expressed and secreted)] in lung tissue.
Macrophages are a source of IL-16 [14], a chemoattractant cytokine which may attract CD4 and CD8 T cells to the site of ovulatory rupture, as reported for injuries in other tissues [15].
Airway epithelium responds to pathogens by producing antimicrobial molecules, proinflammatory cytokines such as interleukin-1 beta (IL-1[beta]), IL-6, tumor necrosis factor alpha (TNF-[alpha]]), and chemokines (IL-8, eotaxin, and macrophage chemoattractant protein-1) which recruit cells belonging to the innate immunity such as macrophages, dendritic cells, and neutrophils (PMN) in order to mount an inflammatory response and control early stages of infection [4, 5].
First, we consider egg-derived chemoattractants that act as chemical signposts directing sperm toward unfertilized eggs (sperm chemotaxis).
We found, however, that IL-8 and MCP-1 [already known to be powerful chemoattractants of neutrophils and monocytes, respectively (1)] were negatively associated with neutrophil and monocyte counts, respectively.
b-LPS induces the upregulation of chemoattractants and inflammatory cytokines, including MIP2, MCP-1, TNF-[alpha], and IL-6, and also reduces the expression of leptin and adiponectin in 3T3-L1 adipocytes.
In mammals, sperm gain motility in the male tract, are stored at the ampulla of the oviduct after coitus, and make forays up the oviduct in response to the chemoattractant progesterone (Villanueva-Diaz et aL, 1995; Eisenbach and Gioja-las, 2006; Teves et aL 2006, 2009; Guidobaldi et al 2008).
Macrophage infiltration into tumors is regulated by several cytokines and chemokines, in particular macrophage chemoattractant protein-1 (MCP-1).
Chemokines have a chemoattractant role and are divided into four families based on the location of cysteine residues in the ligands: CXC, CC, C, and CX3C [9].
Because of the scarcity of eosinophils, many important observations were made in conditions in which their numbers are already increased, due to allergic sensitization or experimental helminth infection, such as the discovery of eotaxin (CCL11), a chemoattractant that induces eosinophil accumulation in the skin of sensitized (i.e., eosinophilic) guinea pigs [2,3,18].
After the first discovery of the chemotactic behavior of spermatozoa toward an egg by Dan (1950), sperm chemotaxis has been reported in various animal species (Miller, 1977; Eisenbach, 1999), and chemoattractants that mediate such behaviors have been identified in a few cases (Ward et al., 1985; Coll et al., 1994; Olson et al., 2001; Yoshida et al., 2002).