Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant
protein-1 in human immunodeficiency virus-infected patients with lipodystrophy.
5 Chemokines, a large family of leukocyte chemoattractants
, have become increasingly recognized as important mediators of hepatic inflammation and injury.
protein-1 selectively inhibits the acquisition of CD40 ligand-dependent IL-12-producing capacity of monocyte-derived dendritic cells and modulates Th1 immune response.
If the cell is stimulated by the pro-inflammatory signals: cytokines, endotoxin, modified lipids or reactive oxygen species, it causes activation of an inhibitor necrosis factor of kappa B kinases and the expression of pro-inflammatory mediators: intercellular adhesion molecule-1, vascular cellular adhesion molecule-1, monocyte chemoattractant
protein-1, interleukin-6 and others.
It maximizes IL-6 function as chemoattractant
to stimulate monocytes, macrophages, and other cells in inflammatory and proliferative phases of wound healing .
5) However, several proinflammatory molecules involved in AD that have been identified as promising therapeutic targets include phosphodiesterase-4 (PDE-4), chemoattractant
receptor-homologous molecule expressed on [T.
Wilcox, "Monocyte chemoattractant
protein-1 in human atheromatous plaques," The Journal of Clinical Investigation, vol.
Circulating levels of fatty acid-binding protein 4 (FABP4), monocyte chemoattractant
protein 1 (MCP1), retinol-binding protein 4 (RBP4), interleukin-6 (IL-6), visfatin, tumor necrosis factora (TNF-[alpha]), CTRP1 (all from Biovendor, Brno, Czech Republic), FGF21, and total adiponectin (all from Alpco Diagnostics; Salem, NH, USA) were measured using an enzymelinked immunosorbent assay (ELISA) according to the manufacturer's protocols.
Lundgren, "Pneumocystis carinii major surface glycoprotein induces interleukin-8 and monocyte chemoattractant
protein-1 release from a human alveolar epithelial cell line," European Journal of Clinical Investigation, vol.
To quantitate proinflammatory cytokine production in the lung tumor necrosis factor- (TNF-) a, monocyte chemoattractant
protein- (MCP-) 1, Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES), interleukin- (IL-) 6, IL-10, and IL-12 were determined in BALF by sandwich enzymelinked immunosorbent assay (ELISA) using murine-specific commercial kits (Quantikine Mouse cytokine assay kit, R&D Systems, USA).
19) IL-33 induces the synthesis of IL-6, IL-13, and monocyte chemoattractant
protein (MCP)-1 in microglia, and this induction is increased by IL-33-activated mast cells.
Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant
protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis: Hepatology, 2010; 52: 612-622.