In the first phase of testing at the NIH Chemical Genomics
Center, scientists screened up to 2,800 compounds with about 70 high-throughput assays.
Using high-throughput chemical screening at LSI's Center for Chemical Genomics
to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.
NIH partners include the National Toxicology Program (NTP), administered by the National Institute of Environmental Health Sciences (NIEHS), and the NIH Chemical Genomics
Center (NCGC), part of the NIH Center for Translational Therapeutics (NCTT), housed at the National Human Genome Research Institute (NHGRI).
Researchers in computational biology, chemoinformatics and chemometrics, computer science, and other scientific and computer-related fields in Europe, the US, and Japan discuss methods for computing similarity in chemical spaces; methodologies that combine graph mining and machine learning techniques; important elements of chemoinformatics, including statistical and Bayesian techniques and partial least square methods; the integration of ideas from fields like chemoinformatics, bioinformatics, and systems biology for the development of methods to solving chemical problems; and machine learning for chemical genomics
that requires useful computational approaches to investigate the relationship between chemical space of possible compounds and genomic space of possible genes or proteins.
Novartis Vaccines & Diagnostics, Abbott Laboratories, Genzyme Transplant and Oncology, LIMR Chemical Genomics
Center, the University City Science Center, Crown Bioscience, Bay City Capital, and Safeguard Scientifics, to name just a few.
Human cells of interest, such as liver or skin cells, can be placed in each of 1,536 tiny wells in a single dish, says NIH Chemical Genomics
Center Director Christopher Austin.
These deals represent an important strategic step for VASTox as they strengthen and diversify its drug discovery and development pipeline through the addition of two clinical and two pre-clinical programmes in neurological and ophthalmic diseases, which will provide increased near-term opportunities for high-value licensing and partnership deals; enhance its scientific expertise and capabilities in zebrafish chemical genomics
and carbohydrate chemistry; and boost its scientific infrastructure through the acquisition of two high-tech laboratory facilities in Cambridge and Reading.
Genomics: In June, the National Institutes of Health (NIH) announced the creation of the NIH Chemical Genomics
Center, the first in a consortium of chemical genomics
screening sites planned by the NIH.
In addition, Avalon expects to use its chemical genomics
platform to evaluate VX-944's potential in the treatment of solid tumors.
Graffinity will utilize its novel chemical genomics
technology, and drug fragment approach, to identify small molecule hit compounds against a selection of Lilly's therapeutic targets.
These chemicals come from a broad range of sources, including industrial and consumer products, food additives and drugs, that have been compiled under the Tox 21 collaboration between the EPA, National Institutes of Environmental Health Sciences/National Toxicology Program, National Institutes of Health (NIH)/National Human Genome Research Institute, NIH Chemical Genomics
Center and the Food and Drug Administration.
This new action of digoxin was found by treating engineered human kidney cells with thousands of known drugs in a high-throughput screen at the U-M Center for Chemical Genomics