Jones is program chair, Functional and Chemical Genomics
Research Program and Jeannine Tuttle Rainbolt Endowed Chair in Cancer Research at the Oklahoma Foundation for Medical Research in Oklahoma City.
At the U-M Life Sciences Institute's Center for Chemical Genomics
, the team used HT-DSF to apply heat to amyloids while applying thousands of chemical compounds.
In the first phase of testing at the NIH Chemical Genomics
Center, scientists screened up to 2,800 compounds with about 70 high-throughput assays.
Using high-throughput chemical screening at LSI's Center for Chemical Genomics
to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.
NIH partners include the National Toxicology Program (NTP), administered by the National Institute of Environmental Health Sciences (NIEHS), and the NIH Chemical Genomics
Center (NCGC), part of the NIH Center for Translational Therapeutics (NCTT), housed at the National Human Genome Research Institute (NHGRI).
The NIH now encourages academic researchers to take their targets to the assay stage and beyond, providing high-throughput screening (HTS) assistance from the NIH Chemical Genomics
Researchers in computational biology, chemoinformatics and chemometrics, computer science, and other scientific and computer-related fields in Europe, the US, and Japan discuss methods for computing similarity in chemical spaces; methodologies that combine graph mining and machine learning techniques; important elements of chemoinformatics, including statistical and Bayesian techniques and partial least square methods; the integration of ideas from fields like chemoinformatics, bioinformatics, and systems biology for the development of methods to solving chemical problems; and machine learning for chemical genomics
that requires useful computational approaches to investigate the relationship between chemical space of possible compounds and genomic space of possible genes or proteins.
Among the companies whose experts on best practices will be featured: Pfizer Worldwide Research & Development, Merck & Co., Novartis Vaccines & Diagnostics, Abbott Laboratories, Genzyme Transplant and Oncology, LIMR Chemical Genomics
Center, the University City Science Center, Crown Bioscience, Bay City Capital, and Safeguard Scientifics, to name just a few.
et al., Gene expression-based chemical genomics
identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.
Two NIH institutes have formed a collaboration with the EPA to use the NIH Chemical Genomics
Center's (NCGC) high-speed, automated screening robots to test suspected toxic compounds using cells and isolated molecular targets instead of laboratory animals.
The high-speed robots to be used in the project are from NIH'S Chemical Genomics