chemical carcinogenesis


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chemical carcinogenesis

The induction of malignancy by a known or putative chemical carcinogen, which can be occupational (e.g., aromatic amines, arsenic, benzene, cadmium, chromium ores, soots, tars, vinyl chloride), environmental (e.g., aflatoxin, asbestos, tobacco) or iatrogenic (e.g., alkylating agents, anabolic steroids, phenacetin).
 
Pathogenesis
Initiation of the carcinogenic cascade occurs when an electrophilically reactive chemical (initiator) or, more often, one or more of its metabolites interacts with DNA, and repair of the damaged DNA is unsuccessful; this is followed by a sequence of events known as tumour promotion.
References in periodicals archive ?
Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.
Furthermore, potential roles for these lncRNAs in the regulation of chemical carcinogenesis and DNA replication signaling pathways were identified.
Chemical carcinogenesis. An Acad Bras Cienc 2007; 79(4):593-616.
In this model expression of activated v-Ha-Ras replaces the initiation step (DMBA treatment) of the two-stage chemical carcinogenesis protocol.
The role of glutathione and glutathione transferases in chemical carcinogenesis. Crit.
And it's worth repeating that resveratrol can inhibit all three stages of chemical carcinogenesis, an unusual phenomenon and highly significant in the treatment of cancer.
Epigenetic Regulation in Environmental Chemical Carcinogenesis and its Applicability in Human Health Risk Assessment.
(1)Department of Physiology, Michigan State University, East Lansing, Michigan, USA; (2)lnstitute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, People's Republic of China; (3)Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA
Cancer risk assessment; chemical carcinogenesis, hazard evaluation, and risk quantification.
Inhibitory effects of nigella sativa and saffron on chemical carcinogenesis in mice.
Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis? J Radiat Res (Tokyo) 50(4):281-293.
Topics include the comparative pathology of mammary gland cancers in domestic and wild animals, neoplasia in nonhuman primates, mouse models of breast cancer, comparison of genetically engineered mouse mammary cancer models and human breast cancer by expression profiling, genetically engineered rat models, chemical carcinogenesis of rat and mouse mammary glands, comparative genetics and genomes of rat models, toxicogenomic analyses of genetic susceptibility to mammary gland carcinogenesis in rodents and the applications for breast cancer, and the relationship between comparative medicine, "one medicine," and genomic pathology.