chelate

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chelate

 [ke´lāt]
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in chemotherapy of metal poisoning.

che·late

(kē'lāt),
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

(kē′lāt′)
adj. Zoology
Having chelae or resembling a chela.
n. Chemistry
A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.
tr.v. che·lated, che·lating, che·lates
1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.
2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.
che·la′tion n.
che′la′tor n.

che·late

(kē'lāt)
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

  1. possessing claws or pincer-like appendages.
  2. to combine with a metal ion to form a stable compound.

Chelate

A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine.
Mentioned in: Nephrotoxic Injury
References in periodicals archive ?
The reason that the intensities of IR bands originate from the attached organic moieties usually appear relatively weak because the mass of the bonded chelators in comparison to the bulk mass of silica is quite low [29].
However, it should be noted that the amount of smear increases from the coronal one-third toward the apical one-third, regardless of the chelator, as stated in the studies of Schmidt et al.
Then, each type of silanes was mixed with SiGdNP in molar ratio Gd : chelator = 10 : 1.5.
The use of this oral chelator DMSA is considered safe for children, but it is not recommended for pregnant or lactating women and patients with kidney disorders.
In this study, we hypothesized that in addition to the well-investigated molecular mechanisms for iron and the action of an iron chelator, DFO, their activity may be associated with regulating intracellular calcium.
In the zinc or copper chelating assay, the chelator were able to capture the ions and inhibit the formation of [Zn.sup.2+] or [Cu.sup.2+-] murexide complex which has an absorption maximum at 462 nm where the low absorbance indicate a high chelating activity.
For that reason, in the present study, we have investigated the detailed mechanisms of the cell death pathway caused by the specific zinc chelator TPEN.
However, most synthetic chelators like EDTA and EDDS form complexes with metals which have high stability and contaminate the groundwater (Zeremski-Skoric et al., 2010).
Morphological evidence of ototoxicity of the iron chelator deferoxamine.
Deferoxamine and deferiprone both iron chelators are used now a days but they are very expensive and difficult to use and have many side effects.
Accumulation and extrusion of permeant Ca2+ chelators in attenuation of synaptic transmission at hippocampal CA1 neurons.