chelation


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Related to chelation: EDTA

che·la·tion

(kē-lā'shŭn),
Complex formation involving a metal ion and two or more polar groupings of a single molecule; in heme, the Fe2+ ion is chelated by the porphyrin ring. Chelation can be used to remove an ion from participation in biologic reactions, as in the chelation of Ca2+ of blood by EDTA, which thus acts as an anticoagulant.
[G. chēlē, claw]

che·la·tion

(kē-lā'shŭn)
Complex formation involving a metal ion and two or more polar groupings of a single molecule; can be used to remove an ion from participation in biologic reactions, as in the chelation of Ca2+ of blood by ethylenediaminetetraacetic acid, which thus acts as an anticoagulant in vitro.
[G. chēlē, claw]

chelation

the binding of a metal ion to an organic molecule from which it can later be released. In complex molecules, chelation results in, for example, zinc binding with amino acids in carboxypeptidase enzymes. Some chelating agents, such as penicillamine, are drugs used to treat metal poisoning: the metal is bound to the drug and can then be excreted safely Chelation also enables plants to take up metal ions such as iron that are not readily available in a free state.

Chelation

The process by which a molecule encircles and binds to a metal and removes it from tissue.
Mentioned in: Heavy Metal Poisoning

che·la·tion

(kē-lā'shŭn)
Complex formation involving a metal ion and two or more polar groupings of a single molecule.
[G. chēlē, claw]
References in periodicals archive ?
Food and Drug Administration (FDA) has not approved chelation therapy for any purpose other than heavy metal removal.
Her research into metal analysis and chelation has been published worldwide.
An egg that was produced a day before the initial start of chelation therapy was submitted to the California Animal Health and Food Safety Laboratory for lead testing by inductively coupled mass spectrometry.
BTM children on regular transfusions and suboptimal chelation are at an increased risk for iron overload.
In 2015, chelation was put through a Cochrane review - the gold standard for medical evidence - which found no evidence that it had any effect against autism.
The third treatment relies on mostly vitamins B and C to further help the blood vessels recover from the workout they may receive from hydrogen peroxide and chelation.
Thyroid dysfunction is reported in 26% patients with b-thalassemia major, but its severity and frequency varies in different cohorts according to chelation regimens5-7.
Dr Sibia, Director of a heart centre in Ludhiana in Punjab (India) informed that in addition to Chelation Therapy cardiovascular rehabilitation program should include aggressive lifestyle change for all heart patients with or without angioplasty, stents or bypass surgery specially for patients with complex cardiovascular conditions, such as diabetes, acute myocardial infarction, and multi-vessel coronary artery disease.
Due to the persisting elevated Co/Cr blood levels (Co above 20 mcg/L and Cr above 8 mcg/L) a chelation therapy with oral high-dose NAC (300 mg/kg/day for 9 days) was performed in April 2014 (Figure 1(b)).
Most of the parents were aware about iron overload, but only 48.18% children were receiving iron chelation [Table 2].
Methodology: This study included 100 b-thalassemia major patients who were diagnosed by Hb electrophoresis and were receiving regular blood transfusions for anemia and chelation therapy for prevention of iron overload related complications.