chelate

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chelate

 [ke´lāt]
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in chemotherapy of metal poisoning.

che·late

(kē'lāt),
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

(kē′lāt′)
adj. Zoology
Having chelae or resembling a chela.
n. Chemistry
A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.
tr.v. che·lated, che·lating, che·lates
1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.
2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.
che·la′tion n.
che′la′tor n.

che·late

(kē'lāt)
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

  1. possessing claws or pincer-like appendages.
  2. to combine with a metal ion to form a stable compound.

Chelate

A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine.
Mentioned in: Nephrotoxic Injury
References in periodicals archive ?
To determine whether there is an increased mobilizable lead pool, the size of the chelatable pool in controls must first be measured.
Chelatable lead in relation to lead in bone and ALAD genotype.
Hemin, chelatable iron, and the regulation of transferrin receptor biosynthesis.
The resulting increase in chelatable iron would be expected to lead to a down-regulation of transferrin receptor expression (16).
This finding appears to be in keeping with studies indicating that ascorbic acid may in some manner increase intracellular chelatable iron by facilitating mobilization of iron from the ferritin compartment (4).
Children ALAD BLL, HB 2004 Abbreviations: BLL, blood lead level; BUN, blood urea nitrogen; CBL, calcaneus bone lead; DBP, diastolic blood pressure; DMSA, DMSA- chelatable lead; HB, hemoglobin; PBL, patella bone lead; SBP, systolic blood pressure; SC, serum creatinine; TBL, tibia bone lead; ZPP, zinc protoporphyrin.
A 4-hr urine collection after oral administration of 10 mg/kg dimercaptosuccinic acid (DMSA) was also obtained to measure DMSA chelatable lead and creatinine clearance (787 participants completed this collection).
The estimated concentration of iron bound to the LMW ligands (the so-called chelatable iron) is 1-10 [micro]M in rodent and human cells (Petrat et al.
The chelatable iron pool in living cells: a methodically defined quantity.