Now, though, new drugs that disable these checkpoint proteins
are showing a keen ability to awaken T cells and, in so doing, pull away cancer's veil.
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
Previously it was thought that checkpoint proteins
were only functional in dividing cells.
CEACAM1 is a novel immune checkpoint protein
that belongs to the Human CEA (Carcino-Embryonic Antigen) protein family and is a target for cancer immunotherapy.
The candidates, two GITR agonists and a CTLA-4 antagonist, target cell-surface checkpoint proteins
that control immune responses and are part of the company's recent takeover of German 4-Antibody and the result of a collaboration between 4-Antibody and Ludwig Cancer Research.
As expected from the mechanism of action of rigosertib, the treated cells exhibited downregulation of the PI3K/AKT pathway and cell cycle checkpoint proteins
Pembrolizumab and nivolumab work by targeting and interfering with the activity of cellular checkpoint proteins
called programmed death-1 and programmed death-ligand 1 (PD-L1).
Honokiol affects cell cycle checkpoint proteins
in glioma cells.
This collaborative research will expand Compugen's ongoing assessment of the biology and mechanism of actions of its novel B7/CD28-like immune checkpoint proteins
, and provide access to the world-class immuno-oncology research tools and expertise at Johns Hopkins University.
Determining how checkpoint proteins
, special proteins that assess DNA damage, impact tumor progression and resistance to cancer therapies.
Elucidation of the checkpoint proteins
amenable to over-expressed PCGEM1 may enable their scrutiny as potential anticancer therapeutic targets in prostate cancers that show elevated PCGEM1.
School of Medicine, Tuxedo, NY) introduces 13 chapters by international researchers summarizing advances made since the 1980s in identifying components of cell-cycle checkpoints, their regulation during checkpoint activation, and validation of the use of checkpoint proteins
as targets for developing effective anticancer drugs.