chaperones


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chaperones

Chaperonins, intracellular proteins that assist in the correct folding of other proteins by means of hydrophobic surfaces that recognize and bind to exposed hydrophobic surfaces on misfolded proteins. Chaperones also assist proteins to arrive at the sites in the cell where they carries out their function. Intracellular proteins with abnormal configurations interact abnormally with other molecules, and many disease processes relate to misfolded proteins. Misfolding of proteins that are regulators of growth and differentiation and contribute to ageing and many diseases. It may, for instance, may be an important factor in the causation of cancers. Protein misfolding may be a factor in as many as half of all diseases. Increasing understanding of this phenomenon may lead to new and important therapies.
References in periodicals archive ?
Examining how chaperones are used in texts to promote a specific frame and/or position is critical.
The hospital's chaperone policy required either a family member or another professional to chaperone any intimate examination.
Chaperones 1-deoxynojirimycin and its analogues have been tried for chaperone therapy in this disease.
While most chaperones machines such as DnaK-Dnaj-GrpE or GroEL-GroES consume energy, sHSPs are generally believed to be ATP independent.
It was a mountain out of a molehill," Yeshivah of Flatbush teacher Marian Wielgus, one of the eight chaperones, told CNN.
Drug development has focused on the chaperone Hsp90 (heat shock protein 90) because it plays a key role in assisting mutated proteins, making it an attractive cancer drug target.
COMMON SENSE: Pupils give thumbs up to chaperones being reinstated on their school bus at Bishop's Tachbrook CE Primary.
Professionalism in the intimate examination: How healthcare practitioners feel about having chaperones present during an intimate consultation and examination.
Just think about it a minute: A bunch of Secret Service agents guarding the president get caught up in a prostitution scandal, and some genius in the government decides we need to supply them with chaperones.
Protein chaperones and protection from neurodegenerative diseases.
These dances are for students in grades 5, 6, 7, and 8 only and there are several adult chaperones to ensure everyone's safety.
So, what is an intimate examination, what is a chaperone, and what are the implications of chaperones being present during these examinations?