chalones


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chalones

POLYPEPTIDEs or glycoproteins, released by actively-dividing cells that inhibits chromosomal reproduction (MITOSIS) in cells of the tissue in which they are formed, thus controlling a tendency to HYPERPLASIA.
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The lipoxins were the first identified and recognized endogenous anti-inflammatory lipid mediators which can function as "braking signals" for neutrophils or chalones in inflammation [30].
Thumann & Bustos-Obregon (1978) postulated that this response is mediated by the spermatogonial chalones, an inhibitor of spermatogonial mitosis produced by spermatogenic differentiated cells.