challenge

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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response
References in periodicals archive ?
Aviation, a world-class aircraft flight management and charter aircraft company, has expanded its fleet with its latest addition of two industry-leading Challenger 350 aircraft.
The tournaments are joint ATP Challenger Tour/WTA 125K Series events and pay equal prize money, $162,000 per tour, for a total of $324,000.
Challenger aircraft are assembled at Bombardier Aviation's multifaceted facility in Montreal, Quebec.
Challenger 650 aircraft feature an advanced wing design that minimizes the effect of turbulence, resulting in a smoother ride from takeoff to landing.
The AWD version of the Challenger GT has an EPA-estimated 18/27/21 mpg city/highway/combined.
Following the Sale, Challenger will retain its equity stake in the New York Wheel LLC, with a minimum of two equity units and up to three equity units depending on the closure of at least one project by Starneth in the next two years.
He said, 'We are Britain's biggest challenger bank, but we want to really take on those big guys.
e Challenger is capable of transcontinental ight with a range of 3,200 nautical miles (5,926km) and features luxury cabin space that can accommodate 10 passengers.
Popular Mechanics magazine calls the top-of-the-line, new-for 2015 Challenger SRT Hellcat the ''wildest muscle car Detroit (has) ever built'' and named it ''Best Muscle Car'' for 2015.
Thomas Bradtke, partner and managing director in BCG's Dubai office and originator of its Global Challenger report series in 2006, said: "Eight years ago, when we created the global-challenger list, it was dominated by Chinese and Indian manufacturers that largely competed on the basis of low costs.
The sexy singer who dropped a self-titled visual album in December has ended up being slammed for using the voice clip of the ill-fated Challenger space ship in her music video of "XO."