cetirizine hydrochloride


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cetirizine hydrochloride

All-Day Allergy, Aller-Relief, Allergy Relief, Benadryl Allergy Oral Solution (UK), Benadryl One a Day (UK), Piriteze (UK), Pollenshield Hayfever (UK), Reactine, Zirtec (UK), Zyrtec

Pharmacologic class: Histamine1-receptor antagonist (peripherally selective)

Therapeutic class: Allergy, cold, and cough agent; antihistamine

Pregnancy risk category B

Action

Antagonizes histamine's effects at histamine1-receptor sites, preventing allergic response. Also has mild bronchodilatory effects and blocks histamine-induced bronchoconstriction in asthma.

Availability

Syrup: 5 mg/5 ml

Tablets: 5 mg, 10 mg

Indications and dosages

Allergic symptoms caused by histamine release
Adults and children older than age 6: 5 to 10 mg P.O. daily
Children ages 2 to 5: 2.5 to 5 mg P.O. daily

Dosage adjustment

• Renal impairment

• Hepatic impairment

Contraindications

• Hypersensitivity to drug or hydroxyzine

• Acute asthma attacks

• Angle-closure glaucoma

• Pyloroduodenal obstruction

• Breastfeeding

Precautions

Use cautiously in:

• renal impairment, significant hepatic dysfunction

• elderly patients

• pregnant patients

• children younger than age 2 (safety not established).

Administration

• Give with or without food.

• Administer at same time each day.

Adverse reactions

CNS: dizziness, drowsiness, fatigue

CV: palpitations, edema

EENT: pharyngitis

GI: nausea, vomiting, abdominal distress, dry mouth

Musculoskeletal: myalgia, joint pain

Respiratory: bronchospasm

Skin: photosensitivity, rash, angioedema

Other: fever

Interactions

Drug-drug. CNS depressants: additive CNS effects

Theophylline: decreased cetirizine clearance

Drug-diagnostic tests. Allergy skin tests: false-negative results

Drug-behaviors. Alcohol use: additive CNS effects

Sun exposure: photosensitivity

Patient monitoring

• Monitor creatinine levels in patients with renal dysfunction.

• Assess hepatic enzyme levels in patients with hepatic disease.

Patient teaching

• Tell patient to take with full glass of water.

• Inform patient that drug may impair alertness and that alcohol may exaggerate this effect.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

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References in periodicals archive ?
Amount of cetirizine hydrochloride loaded in formulations of Ge/SA hydrogels Amount of CTZ HCl loaded (g/g of dry gel) Sample codes By swelling By extraction [S.sub.4] 0.078 0.0715 [S.sub.5] 0.082 0.0798 [S.sub.6] 0.083 0.0802 [S.sub.7] 0.078 0.0750 [S.sub.8] 0.073 0.0699 [S.sub.9] 0.06225 0.0604 Ge/SA: Gelatin/sodium alginate, CTZ HCl: Cetirizine dihydrochloride Table 4.
Amin, "Formulation and characterization of rapidly dissolving films of cetirizine hydrochloride using pullulan as a film forming agent," Indian Journal of Pharmaceutical Education and Research, vol.
In this experimental study, cetirizine hydrochloride has been observed as suitable drug to prepare its gel for transdermal drug delivery on the basis of its physical, chemical, and biopharmaceutical features (Khan et al., 2011a).
Review of cetirizine hydrochloride for the treatment of allergic disorders.
The company revealed the cetirizine hydrochloride oral solution USP, 1 mg/mL, bubble gum flavored is the store brand equivalent to Children's Zyrtec Allergy Syrup, 1 mg/mL, bubble gum flavored.
This randomized parallel group study of 83 patients with multiple sclerosis who had recently begun glatiramer acetate therapy investigated whether administration of an oral antihistamine (cetirizine hydrochloride; Zyrtec, 10 mg) prior to each daily subcutaneous injection of glatiramer acetate would lower the incidence of LISRs compared with an oral placebo.
FDA has given final approval to Perrigo Company to manufacture and market over-the-counter (OTC) Children's Cetirizine Hydrochloride Oral Solution (Allergy) and Children's Cetirizine Hydrochloride Oral Solution (Hives-Relief), 1mg/mL.
Zyrtec (cetirizine hydrochloride) reduced hot flashes by 40% in a placebo-controlled study of 100 postmenopausal women, Dr.
Terfenadine, clemastine fumurate, and cetirizine hydrochloride were evaluated in these 3 studies.
Tenders are invited for Tab Cetirizine Hydrochloride 10Mg In Strip
24 May 2011 - US-based pharmaceutical company Taro Pharmaceutical Industries Ltd (PINK: TAROF) reported yesterday that it has received approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Cetirizine Hydrochloride Oral Solution, 1 mg/mL (Sugar Free Bubble Gum).