cervical intraepithelial neoplasia


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neoplasia

 [ne″o-pla´zhah]
the formation of a neoplasm.
cervical intraepithelial neoplasia (CIN) dysplasia of the cervical epithelium, often premalignant, characterized by various degrees of hyperplasia, abnormal keratinization, and the presence of condylomata.
multiple endocrine neoplasia (MEN) a group of rare hereditary disorders of autonomous hyperfunction of more than one endocrine gland. In Type I (MEN I), called also Wermer's syndrome, there are tumors of the pituitary, parathyroid gland, and pancreatic islet cells in association with a high incidence of peptic ulcer. Type II (MEN II), called also Sipple's syndrome, is characterized by medullary carcinoma of the thyroid, pheochromocytoma, often bilateral and multiple, and parathyroid hyperplasia. Type III (MEN III), called also mucosal neuroma syndrome, resembles Type II except that parathyroid hyperplasia is rare, the mean survival time is shorter, and there may be neuromas and neurofibromas. All forms are transmitted as autosomal dominant traits.

cer·vi·cal in·tra·ep·i·the·li·al ne·o·pla·si·a (CIN),

dysplastic changes beginning at the squamocolumnar junction in the uterine cervix that may be precursors of squamous cell carcinoma: grade 1, mild dysplasia involving the lower one third or less of the epithelial thickness; grade 2, moderate dysplasia with one third to two thirds involvement; grade 3, severe dysplasia or carcinoma in situ, with two thirds to full-thickness involvement.

cervical intraepithelial neoplasia

Cervical dysplasia, CIN Gynecology Precancerous change of uterine cervical epithelium Screening Pap smears, colposcopy and pelvic exam Peak age 25 to 35 Risk factors Multiple sexual partners, early onset of sexual activity–< age 18, early childbearing–< age 16, Hx of STDs–eg, genital warts, genital herpes, HIV; CIN represents a continuum of histologic changes ranging from CIN 1–formerly, mild dysplasia, to severe dysplasia/carcinoma in situ, CIN 3; the lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive SCC, a tendency that is enhanced by concomitant HPV infection, of which HPV 6 and 11 are associated with the 'garden variety', ie benign condylomas; HPV types 16, 18 occur in CIN 3; types 31, 33, 35, 52, 56 also occur in CIN; 78% of ♀ who are positive for HPV, especially HPV 16 and 18, eventually develop CIN 2-3 Treatment Cone biopsy, laser vaporization or excision, loop electrosurgical excision, cryotherapy. See Carcinoma-in-situ, Cervical cancer, Intraepithelial neoplasia, Dysplasia, Low-grade intraepithelial neoplasia, High-grade intraepithelial neoplasia.
Progression of Cervical Intraepithelial Neoplasia
CIN 1 CIN 2 CIN 3
Regression 60%/50% 40%/43% 33%/–
Persistence 30%/41% 40%/48% 55%/–
Progression to CIN 3 10%/9% 20%/9% NA
Progression to SCC ± 1% 5% ≥ 12%
From Int J Gynecol Pathol 1993; 12:186/Modern Pathol 1990; 3:679.

cer·vi·cal in·tra·ep·i·the·li·al ne·o·pla·si·a

(CIN) (sĕr'vi-kăl in'tră-ep-i-thē'lē-ăl nē-ō-plā'zē-ă)
Dysplastic changes beginning at the squamocolumnar junction in the uterine cervix that may be precursors of squamous cell carcinoma: Grade 1, mild dysplasia involving the lower one third or less of the epithelial thickness; Grade 2, moderate dysplasia with one third to two thirds involvement; and Grade 3, severe dysplasia or carcinoma in situ, with two thirds to full-thickness involvement.

cervical intraepithelial neoplasia (CIN)

A cancer of the cervix that is still confined to the outer layer, the epithelium, and is readily curable. CIN is graded I to III depending on the degree of severity. The principal cause of CIN is the human papillomavirus type 16, and promiscuous sexual intercourse with men is an important risk factor for cervical cancer. But about 1 woman in 5 who have never had heterosexual intercourse carries the papillomavirus.

Cervical intraepithelial neoplasia (CIN)

A term used to categorize degrees of dysplasia arising in the epithelium, or outer layer, of the cervix.
Mentioned in: Cervical Cancer, Pap Test
References in periodicals archive ?
Large loop excision of the transformation zone (LLETZ): a new method of management for women with cervical intraepithelial neoplasia. Br J Obstet Gynaecol.
According to the company, its ADXS-HPV construct is in Phase 2 development for the treatment of cervical intraepithelial neoplasia (CIN) 2/3, recurrent/refractory cervical cancer, and head and neck cancer.
According to the company, the escalation study tested the safety and immunogenicity of VGX-3100 in women previously treated for moderate or severe cervical intraepithelial neoplasia (CIN 2/3), a high grade premalignant lesion that may lead to cervical cancer.
Routine cytology testing should be discontinued after total hysterectomy for benign indications, provided the woman has no history of high-grade cervical intraepithelial neoplasia or adenocarcinoma in situ.
A biopsy showed cervical intraepithelial neoplasia grade 0 (CIN0).
The vaccine prevents persistent infection and cervical intraepithelial neoplasia grades 2 and 3 in young women, but has not been shown to prevent cervical cancer.
* METHODS We reviewed the referral practices of a family medicine residency practice that routinely provides LEEP for biopsy-proven cervical intraepithelial neoplasia requiring treatment.
Within the randomised, double-blind, placebo-controlled trial, patients with low to moderate grade cervical intraepithelial neoplasia (CIN1-2) receive one or two treatments using a new drug-device combination.
(3-6) When a hysterectomy has been performed because of a diagnosis of high-grade cervical intraepithelial neoplasia, up to 7.4% of patients have been reported to develop subsequent vaginal intraepithelial neoplasia (VAIN).
Biotechnology company Advaxis Inc (OTCBB:ADXS) said on Friday that the company has dosed the first patient in its phase II clinical trial in cervical intraepithelial neoplasia (CIN), commonly known as cervical dysplasia.
Human papillomavirus testing alone was more sensitive than conventional cytology for detecting cervical intraepithelial neoplasia, and adding liquid-based cytology to HPV testing only increased the rate of false positives, according to a phase I report from a two-phase randomized controlled trial.

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