ceruloplasmin


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ceruloplasmin

 [sĕ-roo″lo-plaz´min]
an alpha2-globulin of the plasma, being the form in which most of the plasma copper is transported.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min), [MIM*117700]
A blue, copper-containing α-globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms of copper per molecule; involved in copper transport and regulation, and can reduce O2 directly without known intermediates; has ferroxidase and polyamine oxidase activities. Ceruloplasmin is absent in congenital Wilson disease.
[L. caeruleus, dark blue]

ceruloplasmin

/ce·ru·lo·plas·min/ (sĕ-roo″lo-plaz´min) an α2-globulin of plasma believed to function in copper transport and its maintenance at appropriate levels in tissue; levels are decreased in Wilson's disease.

ceruloplasmin

(sə-ro͞o′lō-plăz′mĭn)
n.
A blood glycoprotein to which copper is bound during transport and storage.

ceruloplasmin

[siro̅o̅′lōplaz′min]
Etymology: L, caelum, sky; Gk, plassein, to shape
a blue glycoprotein in plasma that transports 96% of the plasma copper. A major decrease is seen in Wilson's disease.

ceruloplasmin

Ferroxidase Clinical chemistry A dehydrogenase produced in the liver involved in copper detoxification and possibly in mopping up excess oxygen radicals or superoxide anions ↑ in Neoplasms, inflammation, liver disease, rheumatoid arthritis, SLE, pregnancy, OCs, estrogen therapy ↓ in Wilson's disease, Menkes' kinky hair syndrome, hepatitis, cirrhosis, nephrotic syndrome, sprue, scleroderma of small intestine. See Copper.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min)
A blue, copper-containing alpha-globulin of blood plasma; involved in copper transport and regulation, and can reduce O2 directly without known intermediates. Ceruloplasmin is absent in congenital Wilson disease.
[L. caeruleus, dark blue]

Ceruloplasmin

A protein circulating in the bloodstream that binds with copper and transports it.
Mentioned in: Wilson Disease

ceruloplasmin

an alpha2-globulin of the plasma, being the form in which most of the plasma copper is transported. Used as a measure of the copper status of animals.
References in periodicals archive ?
Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin.
The majority of analytes examined (albumin, ALP, AGP, A1AT, ALT, amylase, AST, C3, C4, ceruloplasmin, cholesterol, CK, chloride, CRP, iron, GGT, haptoglobin, HDL-C, IgA, IgG, IgM, LDH, STfR, total protein, transferrin, uric acid, and urea) showed marked individuality, with II values of <0.
Typically, ceruloplasmin is given as mg/dl of serum with a normal range of 20 to 35.
Ceruloplasmin is an [alpha]2-glycoprotein synthesized in hepatocytes that binds plasma copper and has ferroxidase activity.
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.
These metals, are complexed with amino acids (glutathione (GSH), cysteine, histidine), Proteins (metallothioneins, transferrin, ferritin, lactoferrin, hemosiderin, ceruloplasmin, melanotransferrin) (Table 1).
Paroxysmal nocturnal hemoglobinuria panel, ol-antitrypsin, blood copper, ceruloplasmin, sweat test, protein C and S, antithrombin III were in normal limits.
In the intestinal mucosal cell, ferrous iron is bound by apoferritin and then oxidized by ceruloplasmin to ferric iron bound to ferritin.
Assays performed in the plasma were glutathione-S-transferase (GST), vitamin C, ceruloplasmin and antioxidant activity (OAO).
Metal chelators such as transferrin, lactoferrin, and ceruloplasmin that are present in human semen also control lipid peroxidation of the sperm plasma membrane, protecting its integrity (91,97).
Low serum levels of copper and ceruloplasmin in an appropriate clinical context, after six weeks of age, can confirm the diagnosis.