ceruloplasmin


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ceruloplasmin

 [sĕ-roo″lo-plaz´min]
an alpha2-globulin of the plasma, being the form in which most of the plasma copper is transported.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min), [MIM*117700]
A blue, copper-containing α-globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms of copper per molecule; involved in copper transport and regulation, and can reduce O2 directly without known intermediates; has ferroxidase and polyamine oxidase activities. Ceruloplasmin is absent in congenital Wilson disease.
[L. caeruleus, dark blue]

ceruloplasmin

(sə-ro͞o′lō-plăz′mĭn)
n.
A blood glycoprotein to which copper is bound during transport and storage.

ceruloplasmin

Ferroxidase Clinical chemistry A dehydrogenase produced in the liver involved in copper detoxification and possibly in mopping up excess oxygen radicals or superoxide anions ↑ in Neoplasms, inflammation, liver disease, rheumatoid arthritis, SLE, pregnancy, OCs, estrogen therapy ↓ in Wilson's disease, Menkes' kinky hair syndrome, hepatitis, cirrhosis, nephrotic syndrome, sprue, scleroderma of small intestine. See Copper.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min)
A blue, copper-containing alpha-globulin of blood plasma; involved in copper transport and regulation, and can reduce O2 directly without known intermediates. Ceruloplasmin is absent in congenital Wilson disease.
[L. caeruleus, dark blue]

Ceruloplasmin

A protein circulating in the bloodstream that binds with copper and transports it.
Mentioned in: Wilson Disease
References in periodicals archive ?
The present study showed an insignificant decrease in mean ceruloplasmin levels in GDM subjects.
Plasma total protein levels (g l-1) were 34.7+-1.77 and 34.9+-1.68, plasma albumin levels (g l-1) were 12.1+-0.82 and 12.8+-0.83 and plasma ceruloplasmin levels (mg dl-1) were 8.56+-0.74 and 9.63+-0.55 for exposure and control groups, respectively.
In addition, levels of ceruloplasmin, which is an acute phase reactant, were also observed to be elevated, which is paralleled with the BMI increase.
In the control group, plasma copper was positively correlated not only with HDL-c ([r.sub.s] = 0.479, p = 0.015) but also with serum ceruloplasmin ([r.sub.s] = 0.646, p < 0.001), TC ([r.sub.s] = 0.446, p = 0.025), and LDL-c ([r.sub.s] = 0.445, p = 0.029).
The TaqMan assays used were Hs00236810 (for ceruloplasmin) and Hs00172187_m1 (for POLR2A).
Keywords: Wilson's; Hepatolenticular degeneration; Copper; Cerebellar; Hepatic; Kayser fleisher rings; ATP7B; Ceruloplasmin
At the same time, the level of ceruloplasmin, an acutephase protein that binds copper, did not change significantly.
Workup including viral hepatitis, CA-19, ceruloplasmin, anti-mitochondrial antibody, tissue transglutaminase IgA, alpha-fetoprotein, and alpha-1antitrypsin was unremarkable.
Extensive workup for other causes of liver injury was negative including viral hepatitis serologies, anti-nuclear antibodies, smooth muscle antibodies, anti-mitochondrial antibodies, ceruloplasmin, acetaminophen level, and iron studies.
The serum ceruloplasmin was normal, ruling out Wilson's disease; hereditary hemochromatosis DNA mutation was absent; ANA titers were negative; and antismooth muscle antibodies were weakly positive.