ceruloplasmin


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ceruloplasmin

 [sĕ-roo″lo-plaz´min]
an alpha2-globulin of the plasma, being the form in which most of the plasma copper is transported.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min), [MIM*117700]
A blue, copper-containing α-globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms of copper per molecule; involved in copper transport and regulation, and can reduce O2 directly without known intermediates; has ferroxidase and polyamine oxidase activities. Ceruloplasmin is absent in congenital Wilson disease.
[L. caeruleus, dark blue]

ceruloplasmin

/ce·ru·lo·plas·min/ (sĕ-roo″lo-plaz´min) an α2-globulin of plasma believed to function in copper transport and its maintenance at appropriate levels in tissue; levels are decreased in Wilson's disease.

ceruloplasmin

(sə-ro͞o′lō-plăz′mĭn)
n.
A blood glycoprotein to which copper is bound during transport and storage.

ceruloplasmin

[siro̅o̅′lōplaz′min]
Etymology: L, caelum, sky; Gk, plassein, to shape
a blue glycoprotein in plasma that transports 96% of the plasma copper. A major decrease is seen in Wilson's disease.

ceruloplasmin

Ferroxidase Clinical chemistry A dehydrogenase produced in the liver involved in copper detoxification and possibly in mopping up excess oxygen radicals or superoxide anions ↑ in Neoplasms, inflammation, liver disease, rheumatoid arthritis, SLE, pregnancy, OCs, estrogen therapy ↓ in Wilson's disease, Menkes' kinky hair syndrome, hepatitis, cirrhosis, nephrotic syndrome, sprue, scleroderma of small intestine. See Copper.

ce·ru·lo·plas·min

(sĕ-rū'lō-plaz'min)
A blue, copper-containing alpha-globulin of blood plasma; involved in copper transport and regulation, and can reduce O2 directly without known intermediates. Ceruloplasmin is absent in congenital Wilson disease.
[L. caeruleus, dark blue]

Ceruloplasmin

A protein circulating in the bloodstream that binds with copper and transports it.
Mentioned in: Wilson Disease

ceruloplasmin

an alpha2-globulin of the plasma, being the form in which most of the plasma copper is transported. Used as a measure of the copper status of animals.
References in periodicals archive ?
Serum ceruloplasmin a dubious biomarker in Wilson's
Antioxidant defense mechanisms include endogenous antioxidant enzymes such as SOD, catalase, and glutathione peroxidase and nonenzymatic compounds such as glutathione, proteins (ferritin, transferrin, ceruloplasmin, and even albumin), and uric acid, coenzyme Q, and lipoic acid, which are all low-molecular-weight scavengers.
Regulation of ceruloplasmin in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene.
To evaluate indicators of AOS condition, ceruloplasmin, retinol, [alpha]-tocopherol in the blood plasma, as well as reduced glutathione, catalase and SOD in red blood cell mass were tested (Tab.
All the individuals were taken up for serum copper and ceruloplasmin levels.
Study the activity of catalase, copper, ceruloplasmin and other biochemical features in first trimester Iraqi pregnant women.
Comparative study of trace elements and serum ceruloplasmin level in normal and pre-eclamptic pregnancies with their cord blood.
Copper, ceruloplasmin and oxidase activity in sera of normal human subjects, pregnant women, and patients with infection, hepatolenticular degeneration and the nephrotic syndrome.
Free copper is the part of blood copper not covalently bound to ceruloplasmin (Cp).
Freelite[R] serum free light chain assays, IgG subclasses (IgG1 -IgG4), IgG, IgA, IgA Subclasses (IgA1 -IgA2), IgM, IgD, Acid Glycoprotein, Albumin, Albumin CSF, Anti-Streptolysin O, [beta]2-Microbulin, Ceruloplasmin, CH50, Cystatin C, C3c, C4, C1 inactivator, Haptoglobin, IgA CSF, IgG CSF, IgM CSF, Prealbumin, Tetanus toxoid plasma screen (RUO), Transferrin
It has also been reported that the ceruloplasmin level started to increase from the 1st day of admission of the patients, reached a maximum level on the 7th day and consistency in the level was observed until 15th day.