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A waxlike, golden, or yellow-brown pigment first found in fibrotic livers of choline-deficient rats, and also known to be present in some cirrhotic livers (and certain other tissues) of human beings. Ceroid is acid fast, insoluble in fat solvents, and probably a type of lipofuscin although differing from true lipofuscins by failing to stain with Schmorl ferric-ferricyanide reduction stain; it also exhibits autofluorescence. Accumulates in Hermansky-Pudlak syndrome.
[L. cera, wax, + G. eidos, appearance]
Etymology: L, cera, wax; Gk, eidos, form
a golden, waxy pigment appearing in the cirrhotic livers of some individuals, in the GI tract, in the nervous system, and in the muscles. It is an insoluble, acid-fast, sudanophilic pigment.
ceroidA complex of alcohol-insoluble, oxidised polyunsaturated lipid pigment(s) resulting from the peroxidation of unsaturated lipids, which are similar or identical to lipofuscin. Ceroid accumulates in macrophages of the heart, liver, gastrointestinal tract and brain in the elderly, and is thus termed a “wear and tear” pigment; it has been inculpated in age-related organ dysfunction hypovitaminosis E, cathartic colon, and hereditary conditions (e.g., Batten’s disease and sea-blue histiocytosis).
ceroidA complex of alcohol-insoluble, oxidized polyunsaturated lipid pigment(s) resulting from the peroxidation of unsaturated lipids that are similar or identical to lipofuscin; ceroid accumulates in macrophages of the heart, liver, GI tract, and brain in the elderly and is thus termed 'wear and tear' pigment; it has been inculpated in age-related organ dysfunction–see 'garbage can' hypothesis, hypovitaminosis E, cathartic colon, and hereditary conditions–eg, Batten's disease, sea-blue histiocytosis.
an insoluble polymer of oxidized lipid and protein; an acid-fast, sudanophilic, pigment found in the liver, the nervous system and muscle. See also ceroid lipofuscinosis.