cerebrosterol

cer·e·bro·ste·rol

(ser'ē-brō-stēr'ol),
A hydroxylated cholesterol found in the brain and spinal cord.

cerebrosterol

A brain-derived sterol (technically: 24S-hydroxycholesterol) that is found in excessive concentrations in the bloodstream of persons with Alzheimer’s disease.
References in periodicals archive ?
SAGE-718 is a novel, oral, first-in-class oxysterol-based positive allosteric modulator of the N-methyl-D-aspartate receptor, acting in a similar manner as 24(S)-hydroxycholesterol (cerebrosterol), an endogenous modulator of NMDA receptor function.
SAGE-718 may also have potential in the treatment of CNS disorders associated with a high prevalence of anti-NMDA antibodies or reduced levels of plasma cerebrosterol.
The effects of NMDA PAMs on cerebrosterol deficit preclinical models were presented at the 2016 annual meetings of the Society of Biological Psychiatry and the Society for Neuroscience.
Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans.
Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.