cerebral thrombosis

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formation, development, or presence of a thrombus; this can happen whenever the flow of blood in arteries or veins is impeded. Many factors can interfere with normal blood flow: heart failure or physical inactivity may retard circulation generally; a change in the shape or inner surface of a vessel wall may impede blood flow, as in atherosclerosis; a mass may grow inside the body and exert pressure on a vessel; the vessel wall may be injured and roughened by an accident, surgery, a burn, cold, inflammation, or infection; or the blood may thicken in reaction to the presence of a foreign serum or snake venom. adj., adj thrombot´ic.

Sometimes a thrombus detaches itself from the wall and is carried along by the bloodstream. Such a clot is called an embolus, and the condition is known as embolism. A thrombus may form in the heart chambers, such as after coronary thrombosis (see below) at the place where the wall of the heart is weakened, or in the dilated atria in a case of mitral stenosis. Because blood normally flows more slowly through the veins than through the arteries, thrombosis is more common in veins than in arteries.
Venous Thrombosis. This occurs most often in the legs or pelvis; it may be a complication of phlebitis, result from injury to a vein, or occur with prolonged bed rest. The symptoms—a feeling of heaviness, pain, warmth, or swelling in the affected part, and sometimes chills and fever—do not necessarily indicate its severity. Immediate medical attention is necessary in any case. Under no circumstances should the affected limb be massaged.

In thrombosis of superficial veins, bed rest with legs elevated and application of heat to the affected area may be all that is necessary. In thrombosis of deep veins, the affected part must be immobilized to prevent the clot from spreading or turning into an embolus, and anticoagulant drugs may be given. With proper treatment, recovery occurs within a short time unless an embolism develops. Practice management guidelines for venous thromboembolism in trauma patients note that a vena cava filter should be considered in patients at high risk who are not candidates for anticoagulants.
Prevention of Venous Thrombosis. Immobility is a prime factor in the development of thrombosis; hence, all patients should be mobilized as soon as possible after surgery or an illness that requires bed rest or produces paralysis. Those who cannot get out of bed should follow an exercise routine involving either active or passive motion of the extremities.  dehydration also plays a role in the development of thrombosis, and the patient should be kept well hydrated. The use of sequential compression devices, such as graded elastic stockings or automated devices providing intermittent compression to the legs, are widely used and accepted, but there are few clinical studies related to their use. They probably play a role in the prevention of stasis and should be combined with other methods to prevent thromboembolism. Clinical guidelines also support the use of low molecular weight heparin for patients at high risk when the bleeding risk is not considered a problem.
Arterial Thrombosis. The main types of arterial thrombosis are related to arteriosclerosis, although thrombosis can also result from infection or from injury to an artery. Arteriosclerosis may be hereditary or may be brought on by diabetes mellitus. Coronary thrombosis, arterial thrombosis in a coronary artery, is a complication of coronary atherosclerosis. A thrombus in one of these arteries will block part of the blood supply to the heart muscle and cause severe myocardial infarction, which is a medical emergency. Cerebral thrombosis is arterial thrombosis in one of the cerebral arteries; the thrombus obstructs the supply of blood to the brain and results in stroke syndrome. Causes include hardening of the cerebral arteries, hypertension, complications of syphilis or other infections, dehydration, diabetes mellitus, or a violent injury.

In advanced cases of arteriosclerosis, a thrombus may fill up whatever channel remains through a vessel, completely blocking off circulation and causing gangrene. This occurs most frequently in arteries of the legs and is called peripheral thrombosis. The onset, often sudden, is characterized by either a tingling feeling or numbness and coldness in the limb. Pain is not always present. Immediate treatment with anticoagulants is necessary to discourage clotting. If this is not effective, surgery may be required. This condition is most common in the elderly and in diabetics. There are now methods of treatment that may save the limb, such as surgical removal of a thrombus or embolus, or surgery of blood vessels to remove old, narrowed, or deteriorated vessels and replace them with grafts.
cerebral thrombosis arterial thrombosis of a cerebral vessel, which may cause stroke syndrome; see also thrombosis.
coronary thrombosis arterial thrombosis in a coronary artery, which may cause myocardial infarction. See also thrombosis.
deep venous thrombosis (DVT) venous thrombosis of one or more of the deep veins of the lower limb, characterized by swelling, warmth, and erythema; it is frequently a precursor of a pulmonary embolism. See also thrombosis.
venous thrombosis phlebothrombosis.

ce·re·bral throm·bo·sis

clotting of blood in a cerebral vessel.

cerebral thrombosis

Etymology: L, cerebrum + Gk, thrombos, lump, osis, condition
an abnormal condition in which a blood clot forms in a cerebral blood vessel.

cerebral thrombosis

Blockage of an artery supplying the brain with blood so that an area of brain is deprived and suffers injury or tissue death. This is a very common cause of STROKE.

Cerebral thrombosis

A blockage of blood flow through a vessel in the brain by a blood clot that formed in the brain itself.
Mentioned in: Stroke
References in periodicals archive ?
In this study, the patients whom we followed up with a diagnosis of cerebral thrombosis in our clinic are presented and age and gender distribution, clinical findings, etiology, imaging findings, treatment and prognoses are discussed.
The medical records of 11 patients aged between 2 and 17 years (median age: 14 years) who were diagnosed with cerebral thrombosis between December the 1st, 2010 and December 31st, 2014 in Marmara University, Pendik Training and Research Hospital were retrospectively examined in terms of age, gender, clinical findings, etiology, risk factors predisposing to thrombosis, imaging findings, treatment and prognosis.
A diagnosis of cerebral thrombosis was made with brain magnetic resonance imaging (MRI) and brain magnetic resonance venography (MRV).
A patient aged 14 years who presented because of repeated thrombosis was followed up two years ago in another center because of cerebral thrombosis and received anticoagulant treatment for six months.
In the literature, cerebral thrombosis has been usually manifested with seizure and focal signs in infants and young children, whereas headache has been reported with a higher rate and altered consciousness and seizures have been reported more rarely in older children (15).
The radiological investigations which should be performed for a diagnosis of cerebral thrombosis include brain MRI and MR venography.
There are no evidence-based recommendations for treatment of cerebral thrombosis in the pediatric age group because of lack of randomized controlled studies (13).
Antibiotic treatment with intravenous second or third generation cephalosporins is recommended in cases of cerebral thrombosis related with otitis media and mastoiditis (7).
Therefore, patients with cerebral thrombosis should be closely monitored in terms of neurological and ophthalmologic symptoms and follow-up brain imaging should be performed in the first one year in terms of persistence, progression and recanalization of thrombosis or venous stenosis.
As far as we know, prior to this, there is no relevant report of ovarian induction treatment resulted in OHSS, complicated with acute cerebral thrombosis event.