The most common symptoms are headache, neck pain, gait disturbance, muscle weakness, numbness and other abnormal feelings in the arms and legs, visual disturbances, tinnitus, dizziness, dysphagia, hearing loss, and vomiting. However, diagnosis of the disease without radiological evaluation is difficult, as there is no specific finding.[4,12,13] Due to the compression of the cerebellum at the posterior fossa and foramen magnum, the symptoms are related to cerebellar dysfunction
. Typical complaints are dizziness, imbalance, and dysmetria.
The individuals with cerebellar dysfunction
were able to accomplish the tasks and reach the target besides the increased time to complete the task and more need of corrections, decreasing the movement smoothness.
Chu et al., "Autistic-like behaviour and cerebellar dysfunction
in Purkinje cell Tsc1 mutant mice," Nature, vol.
Our study showed that regardless of the F-18 FP-CIT PET results, most patients had cerebellar dysfunction
and there was no significant difference in cerebellar or autonomic symptoms between the normal and abnormal scan groups.
These side effects may be an additional risk in patients with cerebellar dysfunction
; therefore, Watase et al.
(3) Focal neurologic findings are uncommon, but cerebellar dysfunction
, pyramidal dysfunction, and psychiatric symptoms have been reported.
Twelve (12/18) patients had memory deficits, 11 (11/18) patients had personality change, 7 (7/18) patients had disturbance of consciousness, and 3 (3/18) patients showed cerebellar dysfunction
. One patient with LE had progressive motor and sensory polyneuropathy.
While the signs of cerebellar dysfunction
had started acutely, their continuation for more than 2 weeks prompted further investigation for an inherited cause of progressive chronic ataxia (our differential diagnosis included ataxia telangiectasia (no telangiectasia were present clinically and the immunoglobulin levels were normal), abetalipoproteinaemia, Friedreich's ataxia and spinocerebellar ataxia.
Oscillopsia may be the sign of vestibular hyporeactivity and some central diseases as cerebellar dysfunction
. Patients with cerebellar dysfunction
rarely complain spontaneously about altered vision during motion but specific questioning may bring up this symptom and DVA test confirms blurred vision .
No players in the study had dysarthria, Parkinson's Disease or cerebellar dysfunction
Adult onset disease is characterized by slowly progressive ataxia, spasticity, cerebellar dysfunction
or peripheral neuropathy with relative preservation of intellect. Diagnosis is suspected on the basis of clinical findings and radiological findings and confirmed by enzyme assay as was our case.
Taking into consideration the fact that the concept of mentalization was formed by applying the concept of the theory of mind in patients with borderline personality disorder, by adding to the objective and cognitive concept of theory of mind a subjective and affective component , we could assume that cerebellar dysfunction
could play a role in the mentalization problem as well.