Liu, IRF8 Regulates Acid Ceramidase
Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia, J.
In this study we have evaluated the pro-apoptotic effect of ceranib-2, a human ceramidase
inhibitor and of a short-chain C2 ceramide on human lung adenocarcinoma cells, A549 by determining cytotoxicity of these agents by trypan blue assay, apoptosis inducing ability by annexin V and JC-1 staining and ultrastructural alterations by transmission electron microscopy.
Awards for original research papers published in the Hamdan Medical Journal are: - Purification and biochemical characterisation of a second type of neutral ceramidase
from camel (Camelus dromedarius) brain, by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
Purification and biochemical characterisation of a second type of neutral ceramidase
from camel (Camelus dromedarius) brain', by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE
Plexcera Therapeutics, a US-based company that develops human acid ceramidase
to treat related diseases, has been granted an exclusive commercial development licence by Mount Sinai Innovation Partners (MSIP), part of the Icahn School of Medicine at Mount Sinai, it was reported yesterday.
048 RND2, SEMA4D neurons Abbreviations: ACER2, alkaline ceramidase
2; FUT4, fucosyltransferase 4; GCNT1, glucosaminyl (N-acetyl) transferase 1, core 2; MAN1B1, mannosidase, alpha, class 1B, member 1; NEU1, sialidase 1 (lysosomal sialidase); RND2, Rho family GTPase 2; SEMA4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; SGPL1, sphingosine-1-phosphate lyase 1; ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 4; TNFAIP3, tumor necrosis factor, alpha-induced protein 3; TNFR1, tumor necrosis factor binding protein 1.
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase
produce ceramide from sphingosine and acyl-CoA.
As for the mechanism involved in the decreased production of sphingosine in atopic dermatitis, analysis of the activities of ceramidases
, major sphingosine-producing enzymes, revealed that, whereas the activity of alkaline ceramidase
did not differ between patients with atopic dermatitis and healthy controls, the activity of acid ceramidase
was significantly reduced in patients with atopic dermatitis and this had obvious relevance to the increased colonization of bacteria in those subjects.
D-galactosyl-sn -glycerol + 2 carboxylates Ceramidase
It is composed of a calcium compound and a ceramidase
inhibitor, and exhibits three main actions, which have been demonstrated in vitro to promote the structuring and stabilization of the stratum corneum.
Michael Daley of Kimberly-Clark provided details on how controlling ceramidase
can improve skin health.
Drug targeting of sphingolipid metabolism: Sphingomyelinases and ceramidases