cephamycin


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cephamycin

/ceph·a·my·cin/ (sef″ah-mi´sin) any of a family of natural and semisynthetic, β–resistant antibiotics derived from various species of Streptomyces, generally classed as second-generation cephalosporins but more active against anaerobes.

cephamycin

(sĕf-ă-mī′sĭn) [From cepha(losporin) + ″]
A group of antibiotics related to the second-generation cephalosporins, having increased bacterial activity against Enterobacteriaceae but diminished effectiveness against gram-positive bacteria. Members of this class of drugs, e.g., cefoxitin, cefotetan, are often used to treat mixed aerobic/anaerobic infections.
References in periodicals archive ?
Many isolates of Acinetobacter spp have developed resistance to antibiotics, including until now successful, aminopenicillins, ureidopenicillin, cefamandole and cephalothin, cephamycin, cefoxitin, most of the aminoglycosides, chloramphenicol, tetracycline, and the more recent antibiotics, such as cefotaxime, ceftazidime, imipenem, tobramycin, amikacin, and fluoroquinolones [17].
ESBLs are plasmid-mediated [beta]-lactamases that are capable of efficiently hydrolyzing penicillin, narrow and broad-spectrum cephalosporins and monobactams (aztreonam), but they do not hydrolyse cephamycin or carbapenems (imipenem, meropenem).
beta]-Lactam antibiotics are frequently used for Agrobacterium eradication in plant tissues, they are penicillin, cephalosporin, cephamycin, oxacephem, monobactam and carbapenem, and are currently being developed to improve and enlarge antibacterial activity (Demain and Elander, 1999).
CLSI mandates reporting methieillin-/oxacillin-resistant staphylococci resistant to all beta-lactam drugs--penicillins, cephalosporins, cephamycin, and beta-lactam/beta-lactam inhibitors and carbapenems.
Other successful preventive infection-control measures include strict hand washing and restricted use of cephalosporin and cephamycin antibiotics that promote resistance in Acinetobacter [22].
However, cephamycin therapy leads to emergence of plasmid mediated Amp C resistance.
In addition, altered expression of outer membrane proteins constituting porins can also contribute to cephamycin resistance (6).
Detection of AmpC was done Cephamycin Hodge test by using Cefoxitin disc (30 [micro]g) with ATCC Strains of Escherichia coli 25922.
Even though the cephamycin antibiotics--cefotetan, cefmetazole, and cefoxitin--may appear to test susceptible, their usefulness in treating serious infections with ES[beta]L producers is unclear.
In addition, mutation or altered expression of outer membrane proteins constituting porins can also contribute to cephamycin resistance.
Enterobacteriaceae with plasmid-encoded class C cephalosporinases are typically resistant to cephamycins, extended-spectrum cephalosporins, and monobactams (19).