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Related to cephalosporinase: penicillinase
an enzyme that hydrolyzes the CO-NH bond in the lactam ring of cephalosporin, converting it to an inactive product.
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.
cephalosporinase/ceph·a·lo·spo·rin·ase/ (-spor´in-ās) a β-lactamase preferentially acting on cephalosporins.
an enzyme that hydrolyzes the −CO−NH− bond in the lactam ring of cephalosporin, converting it to an inactive product.