centromere


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centromere

 [sen´tro-mēr]
the clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division. adj., adj centromer´ic.
 Position of the centromere in A, metacentric, B, submetacentric, C, acrocentric, and D, telocentric chromosomes. From Dorland's, 2000.

cen·tro·mere

(sen'trō-mēr),
1. The nonstaining primary constriction of a chromosome that is the point of attachment of the spindle fiber; provides the mechanism of chromosome movement during cell division; the centromere divides the chromosome into two arms, and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric).
[centro- + G. meros, part]

centromere

(sĕn′trə-mîr′)
n.
The most condensed and constricted region of a chromosome, to which the spindle fiber is attached during mitosis.

cen′tro·mer′ic (-mĕr′ĭk, -mîr′-) adj.

centromere

(1) An obsolete term for the neck of the sprematozoon. 
(2) Centromere; centromerus [NH3].

cen·tro·mere

(sen'trō-mēr)
The nonstaining primary constriction of a chromosome; the centromere divides the chromosome into two arms and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric).
[centro- + G. meros, part]

centromere

The constriction in a chromosome at which the two identical halves (chromatids) of the newly longitudinally-divided chromosome are joined, and at which the chromosome attaches to the spindle fibre during division (mitosis). The centromere contains no genes.

centromere

a structure occurring at one point along the length of a CHROMOSOME, often visible under the light microscope as a bump or a constriction whose location can help to identify the chromosome. The centromere contains a complex system of fibres called the kinetochore which becomes duplicated when the chromosomes divide into CHROMATIDS. The kinetochore attaches to SPINDLE microtubules during nuclear division. Damaged chromosomes without centromeres (ACENTRIC CHROMOSOMES) fail to move normally during nuclear division.

Centromere

The centromere is the constricted region of a chromosome. It performs certain functions during cell division.
References in periodicals archive ?
As detailed above, even when there is signal overlap, individual chromosomes can be traced following the expected pattern from the short arm telomere through the centromere to the long arm telomere.
Characteristic chromosomal anomalies such as premature centromere separation [PCS, heterochromatin push] and/or ESCO2 mutations on the 8th chromosome are determined on cytogenetic evaluation and molecular studies.2,4,8 Despite the observation of PCS as a characteristic chromosomal finding in most of the RBS cases, there are also some reported cases with normal chromosomes.9 In the case review of Schule et al, altough our case had the same mutation with their third case, no cardiac pathology was observed.
Other new and emerging antibodies such as topoisomerase-I (topo-I), centromere protein (CENP)-B, RNA polymerase I-III (RNA-pol I-III), MU, TM, Ku, Mi-2, and RA33 have also been identified.
grossum full synapsis of spermatocytes is only achieved by the three shortest bivalents, whereas the remaining bivalents show incomplete synapsis, restricted to regions near centromeres (Fig.
Although many of the Cyperaceae have not yet been studied, all observations indicate that diffuse centromeres are a synapomorphy for the Cyperales (Greilhuber, 1995) and that agmatoploid chromosome evolution predominates
virginica, and it also provides clear and unambiguous separation of chromosome 5 from chromosome 6, based on differences in the chromosomal position of the 5S rRNA locus (immediately next to the centromere on chromosome 5).
Premature centromere division: a mechanism of non disjunction causing X chromosome aneuploidy in somatic cells of man.
(15) Therefore, the 2013 ASCO/CAP guidelines indicate that alternative testing may be useful for excluding coamplification of the centromere for cases with a HER2 copy number ranging between 4 and 5.9 when the HER2:CEP ratio is less than 2 (because of a CEP17 copy number >2).
The researchers looked for inherited single nucleotide polymorphisms -- inherited changes in a single letter of DNA -- that would allow them to map haplotypes in the centromere.
For a more precise characterization, FISH analysis was performed using POSEIDON centromeric and subtelomeric probes containing chromosome 18 centromere probe, SE18 (D18Z1), and a probe for subtelomeric region of the short arm of chromosome 18 in 40 metaphase spreads (figure 4).
The standard chromosome 17 centromere reference probe (CEP17) is in close proximity to the HER2 locus and may be coamplified, leading to equivocal results.