VF changes are typically bilateral with dense central or centrocecal scotoma with no relationship to the vertical midline and preservation of the peripheral VF.
The anatomical basis of centrocecal sotoma has to be established .
Initially, LHON patients experience painless vision loss, which is severe and associated with dense central or centrocecal
scotoma and impaired colour vision.
OPA1 mutations lead to ADOA type 1, a neuroophthalmic disorder that typically starts during the first decade of life and is characterized by slowly progressive bilateral visual loss, dyschromatopsia, centrocecal
scotomas, and temporal optic disk atrophy.
(3) showed that confrontation testing had a high sensitivity (75% to 100%) for detecting altitudinal visual loss, central/ centrocecal
scotoma and homonymous hemianopia.
A study of patients with acute optic neuritis demonstrated that 48.2% of affected eyes had diffuse visual field loss, 8.3% of affected eyes had central or centrocecal
scotoma, and altitudinal or other nerve-fibre bundle-type defects were present in 20.1% of eyes (23).