sup] According to immunoglobulin gene analysis, EBV-positive and EBV-negative BL revealed two distinct cells of origin, EBV-negative BL has a lower average mutation frequency than EBV-positive BL, indicating an origin in the early centroblast
for sporadic EBV-negative BL, and EBV-positive BL corresponding to the late-GC B-cells that have begun the differentiation process into memory B-cells.
A variant of the centroblastic form is the centroblast
with multilobated nuclei (Figure 1, B).
Microscopically, tumor cells of PCNSL, most often composed of centroblasts
and less frequently of immunoblasts, infiltrate the neural parenchyma with diffuse, invasive, or perivascular growth patterns.
The histology of FL is characterized by germinal centers of B lymphocytes, predominantly centrocytes and centroblasts
with follicular growth pattern (2,5).
In Costinean study, miR-155 was up-regulated within in vitro ABC-DLBCL cell lines (OCI-Ly10, OCI-Ly3), but not in centroblasts
(CBs) and germinal centre (GC)-DLBCL cell lines .
Reactive lymphadenitis was second most common finding with 13(26%) cases showing predominantly small lymphocytes, transforming lymphocytes, centrocytes, centroblasts
, tingible body macrophages and few histiocytes.
8 DLBCL arises from mature B cell resembling centroblasts
or immunoblasts with presence of B cell antigens on immunohistochemistry i.
Excisional biopsy was performed and pathologic examination of the specimen showed a lymphoepithelial lesion rich in plasma cells, centroblasts
, and immunoblast-like cells.
Early phases of HIV infection often present with generalised lymphadenopathy and a LN biopsy at this time often shows giant follicles predominantly composed of centroblasts
with a starry-sky pattern.
The tumor cells often resemble normal centroblasts
It is unclear whether rituximab can affect centroblasts
(germinal centre-like cells) reported to be present in the CNS of MS patients, and whether this is required for rituximab to have clinical benefit.
The neoplastic cells vary from small to large, showing folding and cleaving of the nuclei, resembling centrocytes (small- to medium-sized cleaved cells with inconspicuous nucleoli) and centroblasts
(large noncleaved cells with vesicular chromatin and several peripheral nucleoli).