Our results demonstrated more intense caspase 3 immunostaining in hepatocytes around the central veins indicating a centrilobular necrosis
of the liver intoxicated by TAA as mentioned by Omneia et al.
Many studies have speculated that centrilobular injury may be a manifestation of early AIH, and some studies have reported centrilobular necrosis
in 53%-100% of A-AIH cases [4,6,7,10-12,21,27,28].
Neither of these duration stratifications demonstrated a significant relationship with centrilobular necrosis
, pericellular/sinusoidal fibrosis, or portal fibrosis.
In the NSS + APAP, TEMPO + APAP, and nRNP + APAP groups, inflammatory infiltration of lymphocytes, vacuolation, swelling, and centrilobular necrosis
were observed, while pretreatment with [RNP.sup.N] and NAC was found to prevent these histological changes.
In case of organophosphorus and organochlorine poisoning major histopathological changes are centrilobular necrosis
Hepatomegalia and liver color alteration correlated with the microscopic findings of fatty periportal degeneration and coagulative centrilobular necrosis
, alterations compatible with hepatic damage indicated by decrease of serum albumin and increments of globulins, bilirubin and ALP, GGT and AST enzymes.
Consistent with serum ALT and AST levels, histopathological examination of livers of AT (80 mg/kg) treated rats showed distorted architecture with centrilobular necrosis
and various degenerative changes in hepatic cells.
On autopsy, their livers would show massive hepatic centrilobular necrosis
Skeletal muscle necrosis and renal tubular and hepatic centrilobular necrosis
are characteristic histologic findings that differentiate Cassia poisoning from vitamin E and selenium deficiency (15,21,25).
Different mechanisms of hepatocellular toxicity of intravenous amiodarone have been postulated: liver ischaemia due to impaired hepatic perfusion as a result of its well known cardiovascular effects (8,9), immunomediated centrilobular necrosis
and inhibition of cytochrome [P.sub.450] isenozymes which leads to elevation of the plasma concentrations of other hepatotoxic medications (10).
 showed that, among vascular lesions observed after neoadjuvant chemotherapy, only the most severe cases (haemorrhagic centrilobular necrosis
and regenerative nodular hyperplasia) were correlated with intraoperative transfusion requirements.
The livers showed centrilobular necrosis
, with some inflammatory cellular infiltration and prominent inclusion bodies in the hepatocytes (Figure 2B).