centrilobular

(redirected from centrilobular necrosis)
Also found in: Acronyms.

centrilobular

 [sen″trĭ-lob´u-ler]
pertaining to the central portion of a lobule.

cen·tri·lob·u·lar

(sen'tri-lob'yū-lăr),
At or near the center of a lobule, for example, of the liver.

centrilobular

/cen·tri·lob·u·lar/ (sen″trĭ-lob´u-ler) pertaining to the central portion of a lobule.

centrilobular

[sen′trəlob′yələr]
Etymology: Gk, kentron + L, lobulus, small lobe
pertaining to the center of a lobule.

cen·tri·lob·u·lar

(sen'tri-lob'yū-lăr)
At or near the center of a lobule, e.g., of the liver.

centrilobular

Situated at the centre of a LOBULE of an organ, such as the liver.

centrilobular

pertaining to the central portion of a lobule.

centrilobular necrosis
necrosis restricted to the hepatocytes immediately surrounding the central venule. Called also periacinar necrosis.
References in periodicals archive ?
Neither of these duration stratifications demonstrated a significant relationship with centrilobular necrosis, pericellular/sinusoidal fibrosis, or portal fibrosis.
In the NSS + APAP, TEMPO + APAP, and nRNP + APAP groups, inflammatory infiltration of lymphocytes, vacuolation, swelling, and centrilobular necrosis were observed, while pretreatment with [RNP.
In case of organophosphorus and organochlorine poisoning major histopathological changes are centrilobular necrosis (Fig.
15 VPA induced histological changes in the liver are in the form of microvesicular steatosis and centrilobular necrosis.
severe vascular lesions, consisting of haemorrhagic centrilobular necrosis, were increased with the number of cycles [17].
The livers showed centrilobular necrosis, with some inflammatory cellular infiltration and prominent inclusion bodies in the hepatocytes (Figure 2B).
In addition to the acetaminophen studies, a second compound under study is the industrial chemical carbon tetrachloride, a known liver carcinogen also known to cause acute hepatic centrilobular necrosis.
She had markedly abnormal liver-function test and active fulminant hepatitis with extensive centrilobular necrosis.
Initial liver biopsy revealed active fulminant hepatitis with extensive centrilobular necrosis, approximately 25% heparocellular viability; and mixed inflammatory infiltrates consisting of lymphocytes, histiocytes, scattered eosinophils, and occasional neutrophils.
APAP in excessive doses has a potential to cause a fatal hepatotoxicity due to hepatic centrilobular necrosis and has become an important problem (Larson et al.
The major pathologic findings were in the liver, which showed centrilobular necrosis, steatosis, and basophilic inclusion bodies in hepatocytes.
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.