Neither of these duration stratifications demonstrated a significant relationship with centrilobular necrosis
, pericellular/sinusoidal fibrosis, or portal fibrosis.
In the NSS + APAP, TEMPO + APAP, and nRNP + APAP groups, inflammatory infiltration of lymphocytes, vacuolation, swelling, and centrilobular necrosis
were observed, while pretreatment with [RNP.
In case of organophosphorus and organochlorine poisoning major histopathological changes are centrilobular necrosis
15 VPA induced histological changes in the liver are in the form of microvesicular steatosis and centrilobular necrosis
severe vascular lesions, consisting of haemorrhagic centrilobular necrosis
, were increased with the number of cycles .
The livers showed centrilobular necrosis
, with some inflammatory cellular infiltration and prominent inclusion bodies in the hepatocytes (Figure 2B).
In addition to the acetaminophen studies, a second compound under study is the industrial chemical carbon tetrachloride, a known liver carcinogen also known to cause acute hepatic centrilobular necrosis
She had markedly abnormal liver-function test and active fulminant hepatitis with extensive centrilobular necrosis
Initial liver biopsy revealed active fulminant hepatitis with extensive centrilobular necrosis
, approximately 25% heparocellular viability; and mixed inflammatory infiltrates consisting of lymphocytes, histiocytes, scattered eosinophils, and occasional neutrophils.
APAP in excessive doses has a potential to cause a fatal hepatotoxicity due to hepatic centrilobular necrosis
and has become an important problem (Larson et al.
The major pathologic findings were in the liver, which showed centrilobular necrosis
, steatosis, and basophilic inclusion bodies in hepatocytes.
Effects of calcium channel blocking agents on calcium and centrilobular necrosis
in the liver of rats treated with hepatotoxic agents.