centrilobular

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centrilobular

 [sen″trĭ-lob´u-ler]
pertaining to the central portion of a lobule.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cen·tri·lob·u·lar

(sen'tri-lob'yū-lăr),
At or near the center of a lobule, for example, of the liver.
Farlex Partner Medical Dictionary © Farlex 2012

cen·tri·lob·u·lar

(sen'tri-lob'yū-lăr)
At or near the center of a lobule, e.g., of the liver.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

centrilobular

Situated at the centre of a LOBULE of an organ, such as the liver.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Many studies have speculated that centrilobular injury may be a manifestation of early AIH, and some studies have reported centrilobular necrosis in 53%-100% of A-AIH cases [4,6,7,10-12,21,27,28].
Neither of these duration stratifications demonstrated a significant relationship with centrilobular necrosis, pericellular/sinusoidal fibrosis, or portal fibrosis.
In the NSS + APAP, TEMPO + APAP, and nRNP + APAP groups, inflammatory infiltration of lymphocytes, vacuolation, swelling, and centrilobular necrosis were observed, while pretreatment with [RNP.sup.N] and NAC was found to prevent these histological changes.
In case of organophosphorus and organochlorine poisoning major histopathological changes are centrilobular necrosis (Fig.
Hepatomegalia and liver color alteration correlated with the microscopic findings of fatty periportal degeneration and coagulative centrilobular necrosis, alterations compatible with hepatic damage indicated by decrease of serum albumin and increments of globulins, bilirubin and ALP, GGT and AST enzymes.
Consistent with serum ALT and AST levels, histopathological examination of livers of AT (80 mg/kg) treated rats showed distorted architecture with centrilobular necrosis and various degenerative changes in hepatic cells.
On autopsy, their livers would show massive hepatic centrilobular necrosis.
Skeletal muscle necrosis and renal tubular and hepatic centrilobular necrosis are characteristic histologic findings that differentiate Cassia poisoning from vitamin E and selenium deficiency (15,21,25).
Different mechanisms of hepatocellular toxicity of intravenous amiodarone have been postulated: liver ischaemia due to impaired hepatic perfusion as a result of its well known cardiovascular effects (8,9), immunomediated centrilobular necrosis and inhibition of cytochrome [P.sub.450] isenozymes which leads to elevation of the plasma concentrations of other hepatotoxic medications (10).
[17] showed that, among vascular lesions observed after neoadjuvant chemotherapy, only the most severe cases (haemorrhagic centrilobular necrosis and regenerative nodular hyperplasia) were correlated with intraoperative transfusion requirements.
The livers showed centrilobular necrosis, with some inflammatory cellular infiltration and prominent inclusion bodies in the hepatocytes (Figure 2B).