centrilobular

centrilobular

 [sen″trĭ-lob´u-ler]
pertaining to the central portion of a lobule.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cen·tri·lob·u·lar

(sen'tri-lob'yū-lăr),
At or near the center of a lobule, for example, of the liver.
Farlex Partner Medical Dictionary © Farlex 2012

cen·tri·lob·u·lar

(sen'tri-lob'yū-lăr)
At or near the center of a lobule, e.g., of the liver.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

centrilobular

Situated at the centre of a LOBULE of an organ, such as the liver.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
With an overdose of APAP, humans, rats and mice developed acute liver injury that is characterized by centrilobular necrosis and elevation of serum liver enzymes, such as alanine aminotransferase (ALT) (Jaeschke and Bajt 2006; Fannin et al.
Marked histopathological changes as sinusoids, centrilobular vein and portal vessels congestion were seen in this material, quite similar to those observed in rabbits by Tandon et al.
Increases in liver weight, increases in serum levels of liver enzymes, centrilobular necrosis, fatty degeneration, hemosiderin-laden macrophages, and hemorrhage were seen in animals exposed to HC [ATSDR 1997; Fowler 1969; Gorzinski 1985; National Toxicology Program (NTP) 1989; Weeks et al.
The principal treatment-related histopathologic finding was centrilobular necrosis evident in 5 of 5 rats at 18 h postdose.
Lobular areas of decreased attenuation and vascularity (Figure 1, E and F) are described in approximately 80% of patients, with poorly defined centrilobular nodules in approximately 50% of patients.
High- resolution computed tomography of inflation-fixed lungs: pathologic-radiologic correlation of centrilobular emphysema.
In asthmatics, moderate-to-severe central bronchiectasis affecting 3 or more lobes, bronchial wall thickening, mucoid impaction, and centrilobular lung nodules are suggestive of allergic bronchopulmonary aspergillosis (ABPA) (Figure 2).
APAP in excessive doses has a potential to cause a fatal hepatotoxicity due to hepatic centrilobular necrosis and has become an important problem (Larson et al.
The histopathologic findings reveal discrete nonnecrotizing granulomas with centrilobular and bronchiolocentric distribution.
The livers showed centrilobular necrosis, with some inflammatory cellular infiltration and prominent inclusion bodies in the hepatocytes (Figure 2B).
Acetaminophen is hepatotoxic in doses sufficient to deplete glutathione reserves, permitting accumulation of the highly reactive intermediate n-acetyl-p-benzoquinoneimine, which binds to the hepatocellular membrane, and the resulting injury precipitates centrilobular necrosis (2).
The "classic" or characteristic findings include centrilobular ground-glass or nodular opacities with evidence of air-trapping in the mid to upper portion of the lung lobes.