central sleep apnea


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apnea

 [ap´ne-ah]
cessation of breathing, especially during sleep. The most common type is adult sleep apnea. Central apnea in which there is failure of the central nervous system drive to respiration sometimes occurs in infants younger than 40 weeks after the date of conception.
adult sleep apnea frequent and prolonged episodes in which breathing stops during sleep. Diagnosis is confirmed by monitoring the subject during sleep for periods of apnea and lowered blood oxygen levels. Sleep apnea is divided into three categories: (1) obstructive, resulting from obstruction of the upper airways; (2) central, caused by some pathology in the brain's respiratory control center; and (3) mixed, a combination of the two (see above).
Treatment. Obstructive and mixed types are amenable to therapy. Since many sleep apnea patients are overweight, weight loss improves the symptoms. Central sleep apnea is the most difficult to control. Medications to stimulate breathing have not proven beneficial. Mechanical ventilation or administration of oxygen during the night may help some patients.

The most common treatment for obstructive sleep apnea is nasal continuous positive airway pressure, which the patient uses during sleep; the positive pressure exerted prevents the airway from obstructing. Another method that may be tried is a dental appliance to move the jaw forward during sleep. In the most refractory cases, such as when an anatomical airway obstruction can be demonstrated, surgery to remove it may be performed after consultation with a surgeon experienced in evaluating and treating such obstructions. Another treatment that is occasionally used is insertion of a special type of tracheostomy tube that can be plugged during the day for normal use of the upper airway and opened at night to bypass upper airway obstruction
central apnea (central sleep apnea) see adult sleep apnea.
deglutition apnea a temporary arrest of the activity of the respiratory nerve center during an act of swallowing.
initial apnea a condition in which a newborn fails to establish sustained respiration within two minutes of delivery.
late apnea cessation of respiration in a newborn for more than 45 seconds after spontaneous breathing has been established and sustained.
mixed apnea see adult sleep apnea.
obstructive apnea (obstructive sleep apnea) see adult sleep apnea.
primary apnea cessation of breathing resulting when a fetus or newborn infant is deprived of oxygen; exposure to oxygen and stimulation usually restore respiration.
prolonged infantile apnea sudden infant death syndrome.
secondary apnea a period of time following primary apnea during which continued asphyxia of the fetus or newborn, with a fall in blood pressure and heart rate, necessitates artificial ventilation for resuscitation and reestablishment of ventilation.
sleep apnea transient periods when breathing stops during sleep; see adult sleep apnea.

central sleep apnea

Cessation of breathing during sleep secondary to blunted drive to the respiratory muscles. This is not a single disease but comprises several disorders that manifest as apneic episodes during sleep. In general, central sleep apnea is divided into hypercapnic, and eucapnic or hypocapnic. In hypercapnic central sleep apnea, there is alveolar hypoventilation secondary to either abnormal central drive or respiratory muscle weakness. Any disorder that affects either the brainstem or the respiratory muscles can cause this (for example, strokes, muscular dystrophy). Eucapnic or hypocapnic central sleep apnea is mainly seen in association with Cheyne-Stokes respirations, resulting from heart failure and from other kinds of strokes.
See also: sleep-induced apnea.

central sleep apnea

Sleep disorders A type of life threatening sleep apnea due to defective responses to O2 and CO2 in the circulation Mechanism Possibly ↓ sensitivity to CO2. See Sleep apnea syndrome.

cen·tral sleep ap·ne·a

(sentrăl slēp apnē-ă)
Cessation of breathing during sleep secondary to blunted drive to the respiratory muscles. This is not a single disease but comprises several disorders that manifest as apneic episodes during sleep. In general, central sleep apnea is divided into hypercapnic, and eucapnic or hypocapnic.
References in periodicals archive ?
Logan et al., "Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP)," Circulation, vol.
Unlike obstructive sleep apnea, in which a person stops breathing when his or her airway becomes blocked, central sleep apnea occurs when brain areas that control breathing fail.
A less common form of sleep apnea is central sleep apnea, so named because the central control of breathing is abnormal.
Central sleep apnea occurs when the brain temporarily fails to send a signal to the muscles responsible for breathing control [2], and mixed sleep apnea occurs when both central and obstructive sleep apnea are present [5, 6].
Krieger notes that there is another, less common type of sleep disorder called central sleep apnea (CSA), which is caused by lack of proper signaling from your brain to the muscles involved in breathing.
M2 PHARMA-October 9, 2017-Respicardia Inc awarded US FDA approval for implantable device RemedA" System to treat moderate to severe central sleep apnea
Central sleep apnea (CSA) and periodic breathing (PB) have occasionally been described in adults with pulmonary arterial hypertension (PAH) [3].
Sleep apnea is divided into three main types: central sleep apnea syndrome, obstructive sleep apnea syndrome (OSAS), and mixed sleep apnea syndrome.
The trial randomized more than 1,300 patients with heart failure with reduced ejection fraction and central sleep apnea presenting as CheyneStokes respiration to nocturnal treatment with adaptive servo-ventilation.
Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine, as well as to fund corporate general and administrative costs.
Central sleep apnea isn't related to blockage of an airway.
* Apnea: Screen for obstructive and central sleep apnea. Screen for hypoxemia.

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