First, although psychological factors may contribute to central sensitization
and NP in knee OA, [8,33] they were not evaluated in this study.
Recurrent migraine attacks lead to sensitization of the pain receptor of the trigeminal nerve on meninx, resulting in central sensitization
of the caudate nucleus of the trigeminal nerve.
The diagnosis then becomes pain primarily related to RA with central sensitization
, and both need to be addressed in a treatment plan.
over months or years), then there may be little or no new injury occurring at the tissues, but some combination of peripheral and central sensitization
processes could be maintaining the symptoms.
ent kind: educating primary care providers and emergency department physicians on how to recognize chronic pain or central sensitization
syndromes and disseminating the literature showing that narcotics have no long-term benefit in such cases.
Proponents of the popular central sensitization
analogy have put forward five types of evidence --psychophysical, neuroimaging, genetic, neurotransmitters, and treatments--to support their view, but Dr.
Tizanidine, an alpha-2 -adrenergic agonist, exerts effects in both the brain and spinal cord, with effects at the second order dorsal horn neurons and wide dynamic range neurons--the same location implicated in the central sensitization
Researchers believe that central sensitization
, which is a hypersensitivity to pain, may contribute to the clinical pain amplification in OA.
generally involves 2 phases: hyperalgesia, in which the excitatory threshold of the nerve is reset, leading to a lowered stimulatory requirement, and allodynia, in which normally harmless stimuli are interpreted as pain.
Another aspect of central sensitization
is the dysfunction in pain inhibition .
For years, researchers have been trying to elucidate the molecular mechanisms that underlie central sensitization
to develop novel approaches for treating chronic pain conditions.
may be determined using a number of palpable trigger points.