central nervous system depressant

central nervous system depressant

any drug that decreases the function of the central nervous system, such as alcohol, tranquilizers, barbiturates, and hypnotics. Such drugs can produce tolerance, physical dependence, and compulsive drug use. These substances depress excitable tissue throughout the central nervous system by stabilizing neuronal membranes, decreasing the amount of transmitter released by the nerve impulse, and generally depressing postsynaptic responsiveness and ion movement. Larger dosages cause anesthesia and potentially fatal respiratory and cardiovascular depression. Central nervous system depressants elevate the seizure threshold and can produce physical dependence in a relatively short period. After alcohol the most abused depressants are the short-acting barbiturates, especially pentobarbital, secobarbital, glutethimide, methyprylon, and methaqualone. These substances have popular street names on the illicit market, such as "reds" (secobarbital) and "yellows" (pentobarbital). Sudden withdrawal of general central nervous system depressants that have been used in high doses for prolonged periods can be fatal to some individuals.

cen·tral ner·vous sys·tem de·pres·sant

(sentrăl nĕrvŭs sistĕm dĕ-presănt)
Medication used to slow down neuronal activity.

Central nervous system (CNS) depressant

Any drug that tends to reduce the activity of the central nervous system. The major drug categories included in this classification are: alcohol, anesthetics, anti-anxiety medications, antihistamines, antipsychotics, hypnotics, narcotics, sedatives, and tranquilizers.
Mentioned in: Methadone
References in periodicals archive ?
Avoid consuming alcohol; it dramatically reduces your ability to and the speed at which you can respond since it is a neurotoxin and a central nervous system depressant.
Meperidine exerts high central nervous system depressant effects through producing prolonged activation of opioid receptors ([micro]-receptor).
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Alcohol is a central nervous system depressant, although in smaller amounts it may appear to have a mild stimulant effect.
Alcohol is a central nervous system depressant, so what the authors suggest is not unreasonable at all," Dr.
He said: "Methadone is a central nervous system depressant.
It is a central nervous system depressant which, when abused, can produce euphoria, intoxication and hallucinations.
DEG, a substance used in antifreeze and as a solvent, is a central nervous system depressant and potent kidney and liver toxin.
Alcohol is a central nervous system depressant and leads to a decrease in the level of alertness in the brain.
Acute exposure of mice to maneb led to central nervous system depressant effects, including decreased locomotor activity involving the dopaminergic systems (Morato et al.
A 1982 study by Italian researchers showed that chamomile extracts had mild central nervous system depressant activity.

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