central necrosis

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Related to central necrosis: Frank necrosis, necroses, necrotized


 [nĕ-kro´sis, ne-kro´sis] (Gr.)
the morphological changes indicative of cell death caused by enzymatic degradation.
aseptic necrosis necrosis without infection or inflammation.
acute tubular necrosis acute renal failure with mild to severe damage or necrosis of tubule cells, usually secondary to either nephrotoxicity, ischemia after major surgery, trauma (see crush syndrome), severe hypovolemia, sepsis, or burns. See also lower nephron nephrosis.
Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues.
bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.
caseous necrosis caseation (def. 2).
central necrosis necrosis affecting the central portion of an affected bone, cell, or lobule of the liver.
cheesy necrosis caseation (def. 2).
coagulation necrosis death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.
colliquative necrosis liquefactive necrosis.
fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.
liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.
massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.
moist necrosis necrosis in which the dead tissue is wet and soft.
postpartum pituitary necrosis see postpartum pituitary necrosis.
selective myocardial cell necrosis myofibrillar degeneration.
subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also adiponecrosis neonatorum or subcutanea.
Zenker's necrosis hyaline degeneration and necrosis of striated muscle; called also Zenker's degeneration.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cen·tral ne·cro·sis

necrosis involving the deeper or inner portions of a tissue, or an organ or its units.
Farlex Partner Medical Dictionary © Farlex 2012

cen·tral ne·cro·sis

(sen'trăl nĕ-krō'sis)
Cell death involving the deeper or inner portions of a tissue, or an organ or its units.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Retiform and stellate purpura with and without central necrosis is typically seen grossly.
Although noncaseating epithelioid cell granulomas are typical for sarcoidosis, small central necrosis can be found in some granulomas, leading to presumption of tuberculosis.
The left medial sacral ala shows adjacent contrast enhancement with a low intensity central necrosis. Paraspinal musculature appears atrophied, compatible with denervation, and the bladder is significantly distended, consistent with neurogenic retention.
The patient's CT scan showed a large anterior mediastinal mass with central necrosis, diffuse lymphadenopathy, a large left-sided pleural effusion, and multiple pulmonary nodules.
Histopathology showed anaplastic tumor cells arranged in irregular, lobular formation with central necrosis giving it a comedo pattern.
MN-029 selectively disrupts newly-formed tumor blood vessels, shutting down tumor blood flow and causing central necrosis of solid tumors.
Four patients were later found to have central necrosis and clinical deterioration.
By week 12, 30% of the treated tumors showed small areas of central necrosis. They also exhibited a dermal lymphocytic infiltrate with abundant plasma cells, which was focally present around the basaloid cell aggregates.
More advanced cutaneous lesions feature central necrosis. The skin lesions are extremely tender and firm.
The bulla ruptures and may exude a sort of bloody purulent material, followed by central necrosis, a dark brown or black eschar, and edema out of proportion to the size of the lesion.
However, if there is clinical concern, or if the lesion has suspicious features such as central necrosis, heterogeneity, and irregular borders, then additional work-up is recommended.

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