The strongest evidence is for increased central sensitization and decreased central inhibition
of pain signals.
Although the classic steroids such as progesterone, estrogen, and testosterone act via binding to their respective nuclear receptors (progesterone, estrogen, and androgen receptors), neurosteroids allosterically activate the membrane GABA-A receptors and potentiate the central inhibition
, causing anxiolytic, anticonvulsant, analgesic, and sedative effects [7,8].
Quell triggers a central inhibition
effect that "turns down the volume" of pain signals by stimulating the sensory nerves, which causes the brain to release endogenous opioids that ultimately reduce pain signal transmission.
of PDE-11 can cause cerebral vasodilatation and migraine attacks.[sup.2] Four cases of cluster headaches triggered by sildenafil were reported between 1999 and 2006.[sup.6]-[sup.8] Common triggers of cluster headache include exogenous histamine, vasodilators (e.g., alcohol, nitroglycerin), and cigarette smoking.[sup.9] In our case, the patient experienced a cluster headache attack after taking each of two 50-mg sildenafil pills on 2 consecutive days, and a subsequent transition to a cluster headache bout.
Although these symptoms have been shown to arise from neuronal hyperexcitability in the dorsal horn, resulting from enhanced excitatory amino acid (EAA) signaling [7, 8] and/or loss of central inhibition
, the underlying mechanisms responsible for these sensory changes remain poorly understood.
Loss of central inhibition
has been hypothesized to underpin tinnitus and impact auditory acuity.
SWV has been shown to reduce central excitability and increase central inhibition
The evidence to date indicates that its antimanic effect is primarily attributable to this central inhibition
of protein kinase C signaling rather than the antiestrogenic action that has long made the drug a mainstay in the field of breast cancer, according to Dr.
In this article we address the question of whether semantic ambiguity resolution involves the central inhibition
of the non-selected meaning of a homograph.
Our previous experimental and clinical observations indicate that a positive ice-water test represents a release from central inhibition
, analogous to the release of the Babinski sign after pyramidal tract lesions |12, 18, 19~.