central hypothyroidism


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central hypothyroidism

Endocrinology Hypothyroidism caused by pituitary or hypothalamic disease in the guise of tumors or vascular defects

central hypothyroidism

Hypothyroidism due to inadequate secretion of thyroid stimulating hormone (TSH) by the pituitary or of thyrotropin-releasing hormone (TRH) by the hypothalamus or by a malfunction in blood flow between the hypothalamus and the pituitary gland.
See also: hypothyroidism
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References in periodicals archive ?
Treatment of central hypothyroidism is started with 6-8 microgram/kg/day L-thyroxine.
Role of corticotropin-releasing hormone testing in assessment of hypothalamic-pituitary-adrenal axis function in infants with congenital central hypothyroidism. J Clin Endocrinol Metab 2008;93:3794-4803.
Iassin, "High prevalence of central hypothyroidism in adult patients with [beta]-thalassemia major.," Georgian Medical News, no.
Investigations revealed central hypothyroidism, secondary adrenal insufficiency, central hypogonadism and GH deficiency.
We, at present, want to highlight the extreme rarity of the condition and believe that this is the first reported case of hyperprolactinemia in a patient with Sheehan's syndrome in whom hyperprolactinemia persisted despite the adequate replacement for central hypothyroidism.
Evaluation of the adequacy of levothyroxine replacement therapy in patients with central hypothyroidism. J Clin Endocrinol Metab.
If an organic lesion is excluded by CT/MRI in the child with central hypothyroidism, GH testing can be pursued, provided the hypothyroidism is first treated for 6 to 12 weeks.
Central hypothyroidism was diagnosed based on the low free T4 results with a normal TSH.
However, TSH-based screening is more frequently used around the world even though it often leads to central hypothyroidism being overlooked (17).
Two cases with POU1F1 defect and the case with PROP1 defect also had central hypothyroidism.
Loss-of-function of the immunoglobulin super family member 1 gene (IGSF1, OMIM#300888) causes an X-linked syndrome, characterized in males by congenital central hypothyroidism, delayed testosterone rise in puberty despite normal timing of testicular enlargement, adult macro-orchidism, and in some cases deficiencies of prolactin (PRL) and/or growth hormone (GH) (1,2,3).

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