Treatment of central hypothyroidism is started with 6-8 microgram/kg/day L-thyroxine.
Role of corticotropin-releasing hormone testing in assessment of hypothalamic-pituitary-adrenal axis function in infants with congenital central hypothyroidism. J Clin Endocrinol Metab 2008;93:3794-4803.
Iassin, "High prevalence of central hypothyroidism
in adult patients with [beta]-thalassemia major.," Georgian Medical News, no.
Investigations revealed central hypothyroidism, secondary adrenal insufficiency, central hypogonadism and GH deficiency.
We, at present, want to highlight the extreme rarity of the condition and believe that this is the first reported case of hyperprolactinemia in a patient with Sheehan's syndrome in whom hyperprolactinemia persisted despite the adequate replacement for central hypothyroidism.
Evaluation of the adequacy of levothyroxine replacement therapy in patients with central hypothyroidism
. J Clin Endocrinol Metab.
If an organic lesion is excluded by CT/MRI in the child with central hypothyroidism
, GH testing can be pursued, provided the hypothyroidism is first treated for 6 to 12 weeks.
was diagnosed based on the low free T4 results with a normal TSH.
can be missed sometimes as in our second patient.
However, TSH-based screening is more frequently used around the world even though it often leads to central hypothyroidism
being overlooked (17).
Two cases with POU1F1 defect and the case with PROP1 defect also had central hypothyroidism
Loss-of-function of the immunoglobulin super family member 1 gene (IGSF1, OMIM#300888) causes an X-linked syndrome, characterized in males by congenital central hypothyroidism
, delayed testosterone rise in puberty despite normal timing of testicular enlargement, adult macro-orchidism, and in some cases deficiencies of prolactin (PRL) and/or growth hormone (GH) (1,2,3).