central giant cell granuloma


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central giant cell granuloma

An osteodestructive lesion of uncertain pathogenesis, which most commonly occurs in the young female mandible, and is more lytic than peripheral giant cell granuloma.

Imaging
Radiolucent destructive lesion with faint trabeculation and loculation.
 
DiffDx
Giant cell bone tumour, PTH-induced “brown” tumour (hyperparathyroidism).
 
Management
Curettage.
References in periodicals archive ?
The surgical treatment of central giant cell granuloma of the mandible.
Intralesional corticosteroid injection for central giant cell granuloma. A case report.
Central giant cell granuloma of the jaws: a clinical, radiologic and histopathologic study of 26 cases.
Stromal myofibroblasts in central giant cell granuloma of the jaws cannot distinguish between non-aggressive and aggressive lesions.
Cysts-like spaces were also evident in certain areas which were lined by cellular connective tissue wall suggesting both Central Giant Cell Granuloma and aneurysmal bone cyst-like appearance (Figures 3(a) and 3(b)).
Central giant cell granuloma occurs more fre-quently in the mandible than in the maxilla, generally anterior to the first molar and often crosses the mid-line.
(5,6) Here we report a case of Central giant cell granuloma in mandible.
Central giant cell granuloma (CGCG) is a benign but locally destructive lesion of the mandible or maxilla that presents most often in the second and third decades of life.
A clinical and histomorphologic comparison of central giant cell granuloma and the giant cell minor.
The unusual features of this case include the fact that the maxillary tumor was initially diagnosed as a benign central giant cell granuloma. This tumor is pathologically indistinguishable from a giant cell tumor of the bone or a brown tumor of hyperparathyroidism.
Central giant cell granulomas (arising from within the bonel are generally associated with hyperparathyroidism, whereas peripheral giant cell granulomas arising from or near the surface of the bone apparently are not associated with hyperparathyroidism (7); however it is advisable to test for hyperparathyroidism in the latter condition, if multiple lesions occur.

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