central dogma of molecular biology


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central dogma of molecular biology

The outdated principle which states that proteins are made from RNA, which in turn is made from DNA. Other permutations are found in nature; e.g., RNA viruses use a reverse transcriptase to make complementary DNA.
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Editor Witkowski has selected articles that present an insider's view of discoveries that are now seen as landmark achievements, and that relate to the central dogma of molecular biology, which is that DNA makes RNA makes protein, or, "once information has passed into protein it cannot get out again.
It has been 60 years since the discovery of the structure of DNA and the emergence of the central dogma of molecular biology, wherein DNA serves as a template for RNA and these nucleotides form triplets of letters called codons.
Rather, it offers historical accounts, often first-person descriptions, of many of the key discoveries relating to the central dogma of molecular biology as initially expounded by Francis Crick in 1958: "DNA makes RNA makes protein.

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