The resulting oxygen deprivation determines ischaemic necrosis and the formation of hyalinised areas along the PDL space, death of the cementoblast
and the PDL cells, and exposure of the root surfaces to osteoclast activity (Brudvik & Rygh, 1994; Brezniak & Wasserstein).
The remaining studies used other cells and cell lines from human and animal sources: MG63, RAW264.7, ST-2, Saos-2, OCCM-30, MC3T3-E1, C2C12, U2OS, rat-derived PDLCs, or bone marrow-derived osteoblasts and the cementoblast
cell line HCEM-SV40 (Supplement 3).
First described by Dewey in 1927, BC is a benign tumor of cementoblast
origin, in which cementoblasts
form cementum-like disorganized tissue around the root of a tooth or rarely multiple teeth .
tested the capability of PDLSCs cultured on GO/SF or rGO/rSF composite to initiate cementoblast
In the case of molars, in advanced developmental stages the apical loop leaves the external and internal epithelium, the so-called Hertwig epithelial root sheath, which is a structure necessary for the root to achieve the appropriate length; it is later divided and replaced by cementoblast
precursors, called epithelial cell rests of Malassez .
Regulation of cementoblast
gene expression by inorganic phosphate in vitro .
Rue et al., "Human dental follicle cells acquire cementoblast
features under stimulation by BMP-2/-7 and enamel matrix derivatives (EMD) in vitro," Cell and Tissue Research, vol.
Somerman, "Regulation of cementoblast
function by P.
and osteoblast are similar in biological effects.
This space is necessary to provide a channel for the migration of progenitor cells towards and onto the detoxified root surface hence differentiation of cementoblast
, formation of new cementum and periodontal ligament is desired (17, 18).
Amelogenin enhances the proliferation of cementoblast
This subsequently degenerates leading to cementoblast