cellular reprogramming

cellular reprogramming

The use of transcription factors to induce a differentiated somatic cell to become pluripotent.
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References in periodicals archive ?
This cellular reprogramming may be the key to cancer's ability to form new cell types, evolve drug resistance and metastasize to other locations in the body.
"This is an attractive possibility for cellular reprogramming because multiple genes can be targeted at the same time.
As such, epigenetic regulation is critical for cellular reprogramming as elaborated in other direct reprogramming processes [25].
Yasuhiro YAMADA "Development and Application of in vivo Cellular Reprogramming Technology for Regulating Cancer Cell Fate"
Recently, scientists working at the Salk Institute for Biological Studies in California have found a way to reverse aging in mice through a process called cellular reprogramming. They worked on mice that had been genetically engineered to grow old faster.
Now that we have confirmed that it's possible to reprogram wound cells to a very early stage of development we need to study if they can turn into more mature cell types and then study them in our 3D models to see if they will improve healing of chronic wounds," said Behzad Gerami-Naini, Ph.D., first author on the study in Cellular Reprogramming and an assistant professor at Tufts University School of Dental Medicine.
(1) This report is the first-ever publication about successful cellular reprogramming techniques that could generate an entire organ.
But the research offers a new approach to making stem cells and is a major first step in characterizing how cellular reprogramming happens, says Wu.
He heads the laboratory of regenerative medicine at the Clinical Research Center for Pediatric Hematology, Oncology and Immunology where his research interests include Hutchinson-Gilford Syndrome, new methods of cellular reprogramming, molecular mechanisms of skin and cartilage regeneration and personalized medicine in oncology.
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