AMFB is morphologically similar to other invasive mesenchymal cell tumours such as aggressive angiomyxoma (AAM) and cellular angiofibroma and they share many overlapping immunohistochemical and structural features [9,10].
Other differential diagnoses include cellular angiofibroma and vulvovaginal myofibroblastoma.
Fibroepithelial stromal polyp, superficial angiomyxoma, angiomyofibroblastoma, cellular angiofibroma
and smooth muscle tumours also need to be considered in the differential diagnoses of a polypoidal mass in the perineum.
These entities include benign lesions such as sclerotic fibroma, (2) cellular angiofibroma, (3) giant cell angiofibroma, (4) solitary fibrous tumor, (5) medallion-like dendrocyte hamartoma (plaquelike [CD34.sup.+] dermal fibroma), (6) pleomorphic fibroma, (7) cellular digital fibroma, (8) superficial acral fibromyxoma, (9) pleomorphic hyalinizing angiectatic tumor of soft parts, (10) and malignant lesions such as dermatofibrosarcoma protuberans (DFSP).
Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases.
: A benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma.
Microscopically, cellular angiofibroma
demonstrates short stubby nuclei, wispy collagen,numerous (hyalinized) vessels and is stained for CD34 +/-, desmin -/+, SMA -/+ and molecular identification is RB1 deletion.
Its appellation is based on the similarities with cellular angiofibroma
of the female genital tract .
is a rare benign mesenchymal tumor occurring mainly in the superficial soft tissues of the genital region.
was first described by Nucci et al.
Fletcher, "Cellular angiofibroma
: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma," American Journal of Surgical Pathology, vol.
Angiomyofibroblastoma-like tumor (cellular angiofibroma
) in the male inguinal region.