Gell and Coombs classification of drug allergies (6) Type Mechanism Example Type 1 IgE antibodies mast cell/ Penicilin- basophil degranulation anaphylaxis Type 2 IgG against cell surface/ IgM-mediated cytotoxic reaction Quinidine- hemolytic anemia Type 3 Immune complex Cephalexin- storage reaction serum disease Type 4 Delayed type Neomycine-
cell-mediated reaction contact dermatitis Table 4.
Systemic medications may induce different drug-specific immunoinflammatory hypersensitivity responses including type I immunoglobulin E- (IgE-) mediated, type II IgG-mediated, type III immune complex, and type IV T
cell-mediated reactions [1].
Moreover, other mediators such as some key coagulation factors might influence innate immunity as well as
cell-mediated reactions like healing, response to tissue injury, or inflammatory processes [4,5].
Hypersensitivity pneumonitis (HP), originally known as extrinsic allergic alveolitis, is an allergic lung disease caused by the inhalation of organic or inorganic particles that trigger a cascade of immune-complex and
cell-mediated reactions. Bird fancier's lung is one of the most common forms of HP.' It is a unique form of HP in that the offending antigen is a protein, rather than a micro-organism, and is contained in the feathers, serum and guano of birds.
