cell-mediated immune response


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Related to cell-mediated immune response: cellular immunity, humoral immune response

cell-mediated immune response

(sĕl′mē′dē-ā′tĭd)
n.
The immune response produced when sensitized T cells directly attack foreign antigens and secrete lymphokines that initiate the body's humoral immune response. Also called cellular immune response.

cell-mediated immune response

a delayed reaction of the immune system, mediated primarily by sensitized T lymphocytes rather than antibodies. Cell-mediated immune response reactions are responsible for defense against certain bacterial, fungal, and viral pathogens; malignant cells; and other foreign proteins and tissues. Allergic dermatitis is an example of a cell-mediated immune response. Also called cellular hypersensitivity reaction, delayed hypersensitivity reaction, type IV hypersensitivity. Compare anaphylactic hypersensitivity.
References in periodicals archive ?
Activation of cutaneous immunity by percutaneous absorption of chemical through the stratum corneum is well established; however, given the long dissolution half-life for beryllium metal and its alloys, we hypothesized that beryllium particles would have to colocalize with the cutaneous antigen-presenting cell in the epidermis in order to activate a cell-mediated immune response.
Especially important is the evidence that Flunisyn(TM) induces cell-mediated immune responses across multiple influenza A strains.
Assays conducted by the HVTN Central Immunology Laboratories will measure the ability of the vaccine to induce both antibody and cell-mediated immune responses to the HIV gag protein.
Our results will impact multiple physiological and pathological situations involving T cell-mediated immune responses.
Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children.
When combined with disease-specific antigens, the technology creates JuvaVax vaccines capable of activating substantial antibody- and cell-mediated immune responses, particularly induction of cytotoxic T lymphocytes.
The adjuvant complex self-assembles with disease-specific antigens and induces substantial antibody- and cell-mediated immune responses, particularly induction of CD4+ and CD8+ T lymphocytes.
When combined with disease-specific antigens, the technology creates JuvaVax(TM) vaccines capable of activating substantial antibody- and cell-mediated immune responses, particularly induction of cytotoxic T lymphocytes.
The essential components of humoral and cell-mediated immune responses associated with protection must be identified before prophylactic vaccine trials against any pathogen are implemented.
When combined with disease-specific antigens, JVRS-100 is capable of activating substantial antibody- and cell-mediated immune responses, particularly induction of cytotoxic T lymphocytes (CTL).
Phase I clinical trials of a prophylactic DNA Vaccine containing only the HBsAg gene (pPWRG7128) in 95 subjects, showed that vaccination via PMED(TM) was generally well tolerated both locally and systemically, and resulted in seroprotective levels of antibodies and measurable cell-mediated immune responses.