cell-mediated immune response


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Related to cell-mediated immune response: cellular immunity, humoral immune response

cell-mediated immune response

(sĕl′mē′dē-ā′tĭd)
n.
The immune response produced when sensitized T cells directly attack foreign antigens and secrete lymphokines that initiate the body's humoral immune response. Also called cellular immune response.
References in periodicals archive ?
Activation of cutaneous immunity by percutaneous absorption of chemical through the stratum corneum is well established; however, given the long dissolution half-life for beryllium metal and its alloys, we hypothesized that beryllium particles would have to colocalize with the cutaneous antigen-presenting cell in the epidermis in order to activate a cell-mediated immune response. To reach the epidermis, particles would have to traverse the stratum corneum.
Furthermore, cell-mediated immune responses to the vaccine appear to be more dependent on Tlr4 and MyD88 but not necessarily Tlr2.
They might influence the downregulation of innate immune and cell-mediated immune responses due to the inhibition of IL6, IL8, and TNF.
The present report describes the effects of dietary Mekabu fucoidan on the tumor growth of mouse A20 leukemia cells and on T cell-mediated immune responses in T cell receptor transgenic (DO-11 - 10 - Tg) mice.
Cell-mediated immune responses to COPV early proteins.
The HA and NA are included to induce neutralizing antibody responses, whereas the M1 may induce cell-mediated immune responses that provide protection against drifted (i.e., mutated) strains.
receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-.beta.
Both forms are histopathologically characterized by heavily parasitized macrophages and an absence of cell-mediated immune responses in therapy-naive patients (4).
They are involved in expression or adjustment of cell-mediated immune responses or involved in inflammatory responses.
Current activities towards developing more effective treatment strategies for HIV/AIDS-related malignancies include: 1) targeting molecules in the angiogenesis and apoptotic pathways; 2) fortifying the immune system using immunomodulatory molecules, vaccines designed to increase the cell-mediated immune responses to viral antigens, and monoclonal antibodies to eliminate cancer cells; 3) targeting EBV or KSHV to disrupt the viral life cycle; 4) investigating low morbidity anal lesion ablation techniques, and 5) combining standard chemotherapy regimens with biologic therapies.
Recent studies [10, 27, 46] suggest that IL-25 has dual immune-regulatory effects: it can upregulate Th2-mediated immune responses and also downregulate Th1 and Th17 cell-mediated immune responses. Moreover, collagen-induced arthritis (CIA) in a mouse model showed high expression of IL-25 and IL-17 in the early stage of diseases [47].
Cell-mediated immune responses to viruses and tumor-associated antigens may have implications for enhancing our knowledge of the etiology, diagnosis, and treatment of NPC in the near future.